583881-16-7Relevant articles and documents
Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H 1 antagonists. Part i
Furber, Mark,Alcaraz, Lilian,Luckhurst, Christopher,Bahl, Ash,Beaton, Haydn,Bowers, Keith,Collington, John,Denton, Rebecca,Donald, David,Kinchin, Elizabeth,MacDonald, Cathy,Rigby, Aaron,Riley, Rob,Soars, Matt,Springthorpe, Brian,Webborn, Peter
, p. 7702 - 7706 (2013/02/22)
The discovery of potent small molecule dual antagonists of the human CCR3 and H1 receptors is described for the treatment of allergic diseases, for example, asthma and allergic rhinitis. Optimizing in vitro potency and metabolic stability, star