245057-73-2

Usage

Uses

Used in Pharmaceutical Industry:
4-(3,4-DICHLOROPHENOXY)PIPERIDINE is used as a dopamine receptor agonist for its activity in modulating the dopaminergic system. This makes it a candidate for the treatment of neurological disorders such as Parkinson's disease, where dopamine receptor agonists can help alleviate symptoms by mimicking the effects of dopamine in the brain.
Used in Chemical Research:
In the realm of chemical research, 4-(3,4-DICHLOROPHENOXY)PIPERIDINE serves as a valuable compound for the synthesis of various derivatives. These derivatives are investigated for their potential applications in medicine, including the development of new therapeutic agents for neurological conditions.
Used in Agricultural Industry:
4-(3,4-DICHLOROPHENOXY)PIPERIDINE is also considered for use as an insecticide, capitalizing on its ability to disrupt the nervous system of pests. This property makes it a potential candidate for the development of new pesticides that could offer effective pest control while exploring alternatives to traditional insecticides.
Overall, 4-(3,4-DICHLOROPHENOXY)PIPERIDINE is a significant chemical with a broad spectrum of applications, ranging from pharmaceutical interventions for neurological disorders to its potential as an insecticide in agriculture, highlighting its importance in both medicinal and agricultural chemistry.

Upstream product

• 260441-48-3 tert-Butyl 4-(3,4-dichlorophenoxy)-1-piperidinecarboxylate 
• 5382-16-1 4-HYDROXYPIPERIDINE 
• 1435-49-0 3,4-dichlorofluorobenzene 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 95-77-2 3,4-dichlorophenol 

Downstream Products

• 676517-41-2 1,1-dimethylethyl 4-[[4-(3,4-dichlorophenoxy)-1-piperidinyl]methyl]-1-piperidinecarboxylate 
• 676517-49-0 1,1-dimethylethyl 4-[[4-(3,4-dichlorophenoxy)-1-piperidinyl]methyl]-4-hydroxy-1-piperidinecarboxylate 
• 676517-51-4 4-(3,4-dichlorophenoxy)-1-[1-oxo-2-(2-propenyl)-4-pentenyl]piperidine 
• 377741-15-6 2-[4-(3,4-dichlorophenoxy)piperidin-1-yl]-N-[4-(methylsulfonyl)phenyl]ethanesulfonamide 
• 356557-75-0 N-{2-[(3-{4-[(3,4-Dichlorophenyl)oxy]-1-piperidinyl}-2-hydroxy-2-methylpropyl)oxy]-4-fluorophenyl)acetamide hydrochloride 
• 367500-72-9 4-(3,4-Dichloro-phenoxy)-[1,4']bipiperidinyl-1'-carboxylic acid tert-butyl ester 
• 298699-25-9 2-{3-[4-(3,4-Dichlorophenoxy)-1-piperidinyl]propyl}-1H-isoindole-1,3(2H)-dione 
• 298698-99-4 tert-Butyl 2-[4-(3,4-dichlorophenoxy)-1-piperidinyl]ethylcarbamate 
• 1413286-14-2 C₂₄H₂₆Cl₂N₆O₂ 
• 1413286-15-3 C₂₇H₃₂Cl₂N₂O₆S 
• 1413286-16-4 C₂₆H₃₁Cl₂N₃O₄ 
• 1413286-17-5 C₂₉H₃₄Cl₂N₆O₄ 
• 367500-74-1 4-(3,4-dichloro-phenoxy)-[1,4']bipiperidine 
• 367497-18-5 C₂₅H₂₈Cl₂N₂O₅ 

Relevant academic research and scientific papers

AZETIDINE AND SPIROAZETIDINE COMPOUNDS AND USES THEREOF

The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.

The discovery of CCR3/H1 dual antagonists with reduced hERG risk

A series of dual CCR3/H1 antagonists based on a bispiperidine scaffold were discovered. Introduction of an acidic group overcame hERG liability. Bioavailability was optimised by modulation of physico-chemical properties and physical form to del

MMP INHIBITORS AND METHODS OF USE THEREOF

Provided are MMP inhibitors having the Formula (I): wherein R1, R2 and Y are as defined herein, which are useful in the treatment and/or prevention of MMP-mediated diseases and disorders.

NOVEL PIPERIDINES AS CHEMOKINE MODULATORS (CCR)

Compounds of Formula (I) are modulators of chemokine (for example CCR3) activity (for use in, for example, treating asthma).

Chemical compounds

The invention provides compounds of formula (I): as modulators of chemokine and H1 receptor activity. The compounds are especially useful in the treatment of asthma and rhinitis.

Arylpiperazines and their use as metalloproteinase inhibiting agents (MMP)

Arylpiperazines of formula (I) useful as metalloproteinase inhibitors, especially as inhibitors of MMP 13.

Chemical compounds

The invention concerns compounds of formula (I), and their use in therapy, particularly in the modulation of CCR3 activity.

Chemical compounds

The present invention provides a compound of a formula (I): wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of a chemokine (such as CCR3) or H1 mediated disease state.