58412-71-8Relevant academic research and scientific papers
Ugi three-component coupling reaction for the synthesis of 2-(6-oxo-11-phenyl-7,8-dihydrobenzo[b]pyrrolo[1,2-d][1,4]diazocin-5(6H)-yl) -2-phenylacetamide derivatives
Reddy, P. Lakshmi,Ashok Kumar,Lakshmi Devi,Reddy, T. Veera,Reddy, B.V. Subba,Narender
, p. 657 - 661 (2014/01/23)
A three-component, four center Ugi reaction of 3-(1-(2-aminophenyl)-5- phenyl-1H-pyrrol-2-yl)propanoic acid with aromatic aldehyde and t-butyl isocyanide has been achieved to produce a novel class of N-tert-butyl-2-(6-oxo- 11-phenyl-7,8-dihydrobenzo[b]pyrrolo[1,2-d][1,4]diazacine-5(6H)-yl) -2-phenylacetamides in moderate to good yields. 2013 Elsevier Ltd. All rights reserved.
Discovery of S-nitrosoglutathione reductase inhibitors: Potential agents for the treatment of asthma and other inflammatory diseases
Sun, Xicheng,Wasley, Jan W. F.,Qiu, Jian,Blonder, Joan P.,Stout, Adam M.,Green, Louis S.,Strong, Sarah A.,Colagiovanni, Dorothy B.,Richards, Jane P.,Mutka, Sarah C.,Chun, Lawrence,Rosenthal, Gary J.
, p. 402 - 406 (2011/06/26)
S-Nitrosoglutathione reductase (GSNOR) regulates S-nitrosothiols (SNOs) and nitric oxide (NO) in vivo through catabolism of S-nitrosoglutathione (GSNO). GSNOR and the anti-inflammatory and smooth muscle relaxant activities of SNOs, GSNO, and NO play significant roles in pulmonary, cardiovascular, and gastrointestinal function. In GSNOR knockout mice, basal airway tone is reduced and the response to challenge with bronchoconstrictors or airway allergens is attenuated. Consequently, GSNOR has emerged as an attractive therapeutic target for several clinically important human diseases. As such, small molecule inhibitors of GSNOR were developed. These GSNOR inhibitors were potent, selective, and efficacious in animal models of inflammatory disease characterized by reduced levels of GSNO and bioavailable NO. N6022, a potent and reversible GSNOR inhibitor, reduced bronchoconstriction and pulmonary inflammation in a mouse model of asthma and demonstrated an acceptable safety profile. N6022 is currently in clinical development as a potential agent for the treatment of acute asthma.
