5843-46-9

Upstream product

• 99-94-5 p-Toluic acid 
• 79-37-8 oxalyl dichloride 
• 104825-41-4 1,1-Dimethyl-3,3-bis-(4-methyl-benzoyl)-urea 
• 917-61-3 sodium isocyanate 
• 874-60-2 4-methyl-benzoyl chloride 
• 619-55-6 para-methylbenzamide 

Downstream Products

• 54201-24-0 N-(4-Methylbenzoyl)-peroxycarbamidsaeure-tert-butylester 
• 23252-23-5 3-ethyl-2-phenyl-6-p-tolyl-2,3-dihydro-[1,3,5]oxadiazin-4-one 
• 1123689-75-7 C₁₉H₁₆N₄O₂S 
• 56800-16-9 N,N'-carbonylbis(4-methylbenzamide) 
• 5882-95-1 2-Chlorallyl-N-(p-toluoyl)-carbamat 
• 1428619-92-4 2-[5-bromo-2-(4-methylbenzoylimino)benzo[d]thiazol-3(2H)-yl]butanoic acid 
• 1428619-95-7 methyl 2-[5-bromo-2-(4-methylbenzoylimino)benzo[d]thiazol-3(2H)-yl]butanoate 
• 1428619-94-6 N-(5-bromobenzo[d]thiazol-2-yl)-4-methylbenzamide 
• 1428619-93-5 N-(2,5-dibromophenylcarbamothioyl)-4-methylbenzamide 
• 1621584-41-5 N-(2-oxoindolin-6-ylcarbamoyl)-4-methylbenzamide 
• 66913-68-6 1-(N-4-methylbenzoyl-carbamoyl)-2-cyanoaziridine 
• 38354-35-7 5-p-tolyl-[1,2,4]dioxazol-3-one 
• 38354-40-4 5-morpholin-4-yl-5-p-tolyl-[1,2,4]dioxazolidin-3-one 
• 501433-84-7 1-[2-(2-methyl-aziridin-1-yl)-pyridin-3-yl]-3-(4-methyl-benzoyl)-urea 

Relevant academic research and scientific papers

Scalable Synthetic Strategy for Unsymmetrical Trisubstituted s-Triazines

A scalable synthetic strategy to produce a large variety of unsymmetrical trisubstituted 1,3,5-triazines was developed. This protocol applied in situ formed acyl isocyanate from amide to react with amidine, introducing two substituents to the 1,3,5-triazinone ring with a low production cost and a simple workup procedure. The scalability of this method was demonstrated by translating a small-scale procedure to a multi-kilogram-scale synthesis. Chlorination and a further coupling reaction with various nucleophiles could provide unsymmetrical trisubstituted 1,3,5-triazines bearing diverse functional groups.

Synthetic method of substituted benzoyl isocyanate

The invention discloses a preparation method of substituted benzoyl isocyanate, and belongs to the field of pesticide/medicine intermediates. Substituted benzoyl chloride and cyanate react in an organic solvent in the presence of a composite catalyst composed of a Lewis acid and p-toluene sulfonic acid to generate substituted benzoyl isocyanate. The method avoids the use of expensive oxalyl chloride, highly toxic phosgene, and the like, inhibits the generation of side reaction and byproduct namely cyanobenzene, selects the reaction conditions suitable for commercialization, enhances the selectivity and yield of the reaction, and reduces the generation of wastes, production cost, and environmental pollution.

A useful synthesis of 2-acylamino-1,3,4-oxadiazoles from acylthiosemicarbazides using potassium iodate and the discovery of new antibacterial compounds

A useful method for the synthesis of 2-acylamino-1,3,4-oxadiazoles was developed. By using potassium iodate as an oxidant in water at 60 ?C, a wide range of 2-acylamino-1,3,4-oxadiazoles were afforded in moderate to excellent yields within two

Convenient One-Pot Two-Step Synthesis of Symmetrical and Unsymmetrical Diacyl Ureas, Acyl Urea/Carbamate/Thiocarbamate Derivatives, and Related Compounds

A wide range of chemicals such as amides, hydrazides, amines, alcohols, carbazate, and sulfonate were reacted with acyl isocyanates generated by the reaction of primary amides with oxalyl chloride to give symmetrical and unsymmetrical diacyl urea derivatives, acyl ureas/carbamates/thiocarbamates, and related compounds. This method provides means for convenient one-pot, two-step synthesis of compounds bearing urea, carbamate, and other functional groups from cheap and commercially available starting reagents. It is expected that the results presented in this report will expand the medicinal chemist’s toolbox.

Design, synthesis and fungicidal activity of N-substituted benzoyl-1,2,3,4-tetrahydroquinolyl-1-carboxamide

To find a new lead compound with high biological activity, a series of N-substituted benzoyl-1,2,3,4-tetrahydroquinolyl-1-carboxamide were designed using linking active substructures method. The target compounds were synthesized from substituted benzoic acid by four steps and their structures were confirmed by 1H NMR, IR spectrum and elemental analysis. The in vitro bioassay results indicated that some target compounds exhibited excellent fungicidal activities, and the position of the substituents played an important role in fungicidal activities. Especially, compound 5n, exhibited better fungicidal activities than the commercial fungicide flutolanil against two tested fungi Valsa Mali and Sclerotinia sclerotiorum, with EC50 values of 3.44 and 2.63 mg/L, respectively. And it also displayed good in vivo fungicidal activity against S. sclerotiorum with the EC50 value of 29.52 mg/L.

Synthesis and antitumor activity of novel N-benzoyl-N'-substituted pyrimidinyl (thio)semicarbazide derivatives

A series of substituted pyrimidinyl (thio)semicarbazide derivatives were designed and synthesized. The antitumor results showed that the activity of thiosemicarbazide compounds (series II) was generally higher than that of the corresponding semicarbazide derivatives (series I). Among them, IIk displayed higher cytotoxicity against HL-60, BGC-823 and Bel-7402 than that of adriamycin and exhibited broad in vitro cytotoxicity against 13 human tumor cell lines. Meanwhile, the cytotoxic selectivity and anti-multidrug resistance were evaluated, and IIk exhibited selective cytotoxicity against cancer cells in comparison to human normal cells and had significant anti-multidrug resistance capability. The bioassay results showed that IIk showed great promise as a potent lead compound for further antitumor discovery.

Novel acylureidoindolin-2-one derivatives as dual Aurora B/FLT3 inhibitors for the treatment of acute myeloid leukemia

A series of 6-acylureido derivatives containing a 3-(pyrrol-2- ylmethylidene)indolin-2-one scaffold were synthesized as potential dual Aurora B/FLT3 inhibitors by replacing the 6-arylureido moiety in 6-arylureidoindolin-2- one-based multi-kinase inhibitors. (Z)-N-(2-(pyrrolidin-1-yl)ethyl)-5-((6-(3-(2- fluoro-4-methoxybenzoyl)ureido)-2-oxoindolin-3-ylidene)methyl)-2, 4-dimethyl-1H-pyrrole-3-carboxamide (54) was identified as a dual Aurora B/FLT3 inhibitor (IC50 = 0.4 nM and 0.5 nM, respectively). Compound 54 also exhibited potent cytotoxicity with single-digit nanomolar IC50 values against the FLT3 mutant-associated human acute myeloid leukemia (AML) cell lines MV4-11 (FLT3-ITD) and MOLM-13 (FLT3-ITD). Compound 54 also specifically induced extrinsic apoptosis by inhibiting the phosphorylation of the Aurora B and FLT3 pathways in MOLM-13 cells. Compound 54 had a moderate pharmacokinetic profile. The mesylate salt of 54 efficiently inhibited tumor growth and reduced the mortality of BALB/c nude mice (subcutaneous xenograft model) that had been implanted with AML MOLM-13 cells. Compound 54 is more potent than sunitinib not only against FLT3-WT AML cells but also active against sunitinib-resistant FLT3-ITD AML cells. This study demonstrates the significance of dual Aurora B/FLT3 inhibitors for the development of potential agents to treat AML.

Separating agent for enantiomeric isomers

The present invention provides a separating agent for enantiomeric isomers exhibiting high separation power. That is, the present invention provides a separating agent for enantiomeric isomers including, as an active ingredient, a polysaccharide derivative having at least part of hydrogen atoms of hydroxyl groups of a polysaccharide such as cellulose or amylose substituted by at least one of atomic groups represented by the following general formulae (I) and (II): (in the formulae, R represents a substituted or unsubstituted aromatic group, or a linear, branched, or cyclic aliphatic group).

Synthesis, structure and biological activity of some new aroylurea derivatives containing 1,3,4-thiadiazole

In an extensive search for biologically active aroylurea compounds as plant growth regulators, a series of new N-aroyl-N′-[5-(E)-styryl-1,3,4- thiadiazol-2-yl]ureas have been designed and synthesized. Their structures were characterized by IR, 1H NMR, MS, elemental analysis, and single-crystal X-ray diffraction techniques. The preliminary bioassay showed that some of the title compounds exhibited good plant-growth regulating activity. Copyright Taylor & Francis Group, LLC.

CONDENSATION OF ACYL CHLORIDE ON SODIUM CYANATE : PREPARATION OF ACYL ISOCYANATES

The catalytic effects of various metal halides and solvents on the reaction of benzoyl chloride with sodium cyanate were studied.It has been found that SnCl4, and ZnCl2 catalyze the reaction to give the corresponding acyl isocyanates in good yields.The scope of the reaction was studied and a number of aroyl isocyanates and their derivatives were prepared.A few non aromatic isocyanates and their derivatives were also prepared.