58455-91-7

Upstream product

• 53558-70-6 α-(N-benzyloxycarbonyl)amino-benzylphosphonic acid 
• 100-51-6 benzyl alcohol 
• 161084-48-6 benzyl (N-benzyloxycarbonylamino)benzylphosphinite 
• 621-84-1 O-benzyl carbamate 
• 100-52-7 benzaldehyde 
• 67039-21-8 dibenzyl N-benzyloxycarbonylaminobenzylphosphonate 
• 6738-17-6 O-benzyl-N,N'-dicyclohexylisourea 
• 106019-40-3 α-(N-benzyloxycarbonylamino)benzyl-H-phosphonous acid 

Downstream Products

• 106019-44-7 (Benzyloxycarbonylamino-phenyl-methyl)-phosphonic acid monobenzyl ester; compound with adamantan-1-ylamine 

Relevant academic research and scientific papers

Selective cleavage of one ester group in dibenzyl Di-P-nitrobenzyl and dimethyl N-protected aminoalkylphosphonates

Benzyl, p-nitrobenzyl and methyl hydrogen N-protected aminoalkylphosphonates were efficiently prepared by selective cleavage of one ester group in the corresponding diesters using DABCO (1,4-diazabicyclo(2.2.2]octane).

PREPARATION OF BENZYL N-BENZYLOXYCARBONYLAMINOPHOSPHONATES AND -AMINOPHOSPHONITES - THE SCOPE AND LIMITATIONS OF O-BENZYL-N,N'-DICYCLOHEXYLOISOUREA METHOD

Protection of the amino group of aminophosphonic and aminophosphonous acids with benzyl chloroformate followed by esterification of the N-protected derivatives with O-benzyl-N,N'-dicyclohexyloisoureas is described.The esterification of aminobenzylphosphonic and aminobenzylphosphonous acids was studied in some details in order to discuss the scope and limitation of this procedure.The differences in the reactions of aminoalkylphosphonic and aminoalkylphosphonous acids are pointed out.Key words: Aminobenzylphosphonic and -phosphonous acid, N-benzyloxycarbonyl derivatives, esterification, O-benzyl-N,N'-dicyclohexyloisourea, benzyl N-benzyloxycarbonylaminobenzylphosphonate and phosphonite.

Studies on Organophosphorus Compounds; XLI. A Convenient Synthesis of Alkyl Hydrogen α-(Benzyloxycarbonylamino)benzylphosphonates

Alkyl hydrogen α-(benzyloxycarbonylamino)benzylphosphonates are prepared from substituted benzaldehydes, benzyl carbamate, and phosphorus(III) chloride in acetic acid containing thionyl chloride and subsequent alcoholysis.The reactions proceed smoothly at

SYNTHESIS OF PHOSPHONIC MONOESTERS FROM PHOSPHONOUS ACIDS

Phosphonic monoesters are prepared in a two-step procedure by DCC-DMAP mediated esterification of phosphonous acids and oxidation of the resulting phosphonous monoester.

A Convenient Synthesis of Alkyl Hydrogen 1-(Benzyloxycarbonylamino)-alkanephosphonates

Alkyl hydrogen 1-(benzyloxycarbonylamino)-alkanephosphonates are prepared by condensation of 1-(benzyloxycarbonylamino)-alkanephosphonic acids with primary and secondary alcohols in the presence of thionyl chloride in dimethylformamide.