58456-91-0

Usage

General Description

2-Aminomethyl-4-t-butyl-6-iodophenol is a chemical compound with the molecular formula C11H16INO. It is a phenolic compound that contains an amine and iodine functional group. 2-aminomethyl-4-t-butyl-6-iodophenol has a t-butyl group and an aminoethyl group attached to a 4-methylphenol ring. It is used as a reagent in organic synthesis and as a building block in the production of pharmaceuticals and agrochemicals. The compound has potential applications in the synthesis of diverse organic compounds due to its unique structure and reactivity. It is important to handle 2-aminomethyl-4-t-butyl-6-iodophenol with care as it may pose health and environmental hazards.

InChI:InChI=1/C11H16INO/c1-11(2,3)8-4-7(6-13)10(14)9(12)5-8/h4-5,14H,6,13H2,1-3H3

Upstream product

• 2832-19-1 2-Chloro-N-(hydroxymethyl)acetamide 
• 38941-98-9 4-tert-butyl-2-iodophenol 
• 98-54-4 para-tert-butylphenol 

Downstream Products

• 81440-91-7 2-<<<5-(1,1-dimethylethyl)-2-hydroxy-3-iodophenyl>methyl>amino>-4,5-dihydrothiazole 
• 61615-87-0 6-tert-butyl-8-iodo-1'-phenethyl-3,4-dihydro-spiro[benzo[e][1,3]oxazine-2,4'-piperidine] 
• 68967-65-7 1,1-dimethylethyl N-<<5-(1,1-dimethylethyl)-2-hydroxy-3-iodophenyl>methyl>carbamate 
• 81440-86-0 N-<<5-(1,1-dimethylethyl)-2-hydroxy-3-iodophenyl>methyl>guanidine 
• 81440-89-3 2-<<<5-(1,1-dimethylethyl)-2-hydroxy-3-iodophenyl>methyl>amino>-4,5-dihydro-1H-imidazole 
• 65687-13-0 2-(aminomethyl)-4-(1,1-dimethylethyl)-6-iodophenyl hydrogen sulfate 
• 81440-95-1 N,N,N-trimethyl-1-<5-(1,1-dimethylethyl)-3-iodo-2-methoxyphenyl>methanaminium iodide 
• 68967-66-8 2-<<<<(1,1-dimethylethyl)oxy>carbonyl>amino>methyl>-4-(1,1-dimethylethyl)-6-iodophenyl N,N-dimethylsulfamate 
• 81441-03-4 (5-tert-Butyl-2-carbamoylmethoxy-3-iodo-benzyl)-carbamic acid tert-butyl ester 
• 81440-85-9 1-<5-(1,1-dimethylethyl)-3-iodo-2-methoxyphenyl>methylamine hydrochloride 
• 68967-73-7 (5-tert-Butyl-2-ethylsulfamoyloxy-3-iodo-benzyl)-carbamic acid tert-butyl ester 
• 81440-81-5 2-<2-(aminomethyl)-4-(1,1-dimethylethyl)-6-iodophenoxy>acetamide hydrochloride 
• 81440-83-7 2-(aminomethyl)-4-(1,1-dimethylethyl)-6-iodophenyl methanesulfonate hydrochloride 
• 81440-82-6 N,N-diethyl-2-<2-(aminomethyl)-4-(1,1-dimethylethyl)-6-iodophenoxy>acetamide hydrochloride 

Relevant academic research and scientific papers

Synthesis, attempted kinetic resolution and evaluation of [123I]-MK-447 analogues as inflammation radiopharmaceuticals

The non-steroidal anti-inflammatory agent 2-amino-methyl-4-tert-butyl-6-iodophenol hydrochloride (MK-447) and some of its analogues were labelled with 123I and tested in an inflamed rat-paw model. Even though MK-447 has a significant anti-inflammatory activity, and a 2.3 ratio for inflamed site over muscle, its usefullness for scintigraphic detection of inflammation is hindered by its high uptake in the skin. The kinetic resolution of diastereomeric products with chiral dienyl iron complexes was unsuccessful as the signals from the respective 1H and 13C NMR spectra were coincident.

Method of treating autoimmune diseases

3,4-Dihydrospiro-2H-1,3-benzoxazines and pharmaceutical compositions thereof are useful in the treatment of autoimmune diseases.

Substituted 2-aminomethyl-6-iodophenols

Certain substituted 2-aminomethyl-6-iodophenols and their pharmaceutically acceptable acid addition salts wherein the phenyl nucleus may be further substituted with 1 to 3 nuclear substituents are useful as antihypertensive, diuretic and saluretic agents.