2832-19-1

Basic information

• Product Name: N-Methylolchloroacetamide
• Synonyms: n-methylol-chloracetamide;2-CHLORO-N-(HYDROXYMETHYL)ACETAMIDE;N-METHYLOLCHLOROACETAMIDE;N-HYDROXYMETHYL-2-CHLOROACETAMIDE;N-HYDROXYMETHYLCHLOROACETAMIDE;N1-HYDROXYMETHYL-2-CHLOROACETAMIDE;TIMTEC-BB SBB004273;N-Hydromethyl-2-Chloroacetamide
• CAS NO: 2832-19-1
• Molecular Formula: C₃H₆ClNO₂
• Molecular Weight: 123.54
• EINECS: 220-598-9
• Product Categories: Amides;Carbonyl Compounds;Organic Building Blocks;N-Methylolchloroacetamide ada@tuskwei.com sky;18031153937@189.cn
• Mol File: 2832-19-1.mol
• Article Data: 13

Chemical Properties

• Melting Point: 100-105 °C(lit.)
• Boiling Point: 374 °C at 760 mmHg
• Flash Point: 180 °C
• Appearance: White or almost white crystalline powder
• Density: 1.2776 (rough estimate)
• Vapor Pressure: 4.02E-07mmHg at 25°C
• Refractive Index: 1.5000 (estimate)
• Storage Temp.: 0-6°C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 12.63±0.46(Predicted)
• Water Solubility: Very soluble in water. Poorly soluble in aliphatic hydrocarbons.
• Sensitive: Hygroscopic
• BRN: 1811765
• CAS DataBase Reference: N-Methylolchloroacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-Methylolchloroacetamide(2832-19-1)
• EPA Substance Registry System: N-Methylolchloroacetamide(2832-19-1)

Safety Data

• Hazard Codes: C
• Statements: 34-43-40-20/21/22
• Safety Statements: 26-27-36/37/39-45
• RIDADR: UN 3261 8/PG 2
• WGK Germany: 3
• RTECS: AB5733000
• TSCA: Yes
• HazardClass: 8
• PackingGroup: Ⅱ
• Hazardous Substances Data: 2832-19-1(Hazardous Substances Data)

Usage

Chemical Properties

White or almost white crystalline powder

Uses

Different sources of media describe the Uses of 2832-19-1 differently. You can refer to the following data:
1. N-Methylolchloro-acetamide is a preservative in cooling fluids and cosmetics.
2. An organic building block. It is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals. As dyestuff intermediate .
3. 2-Chloro-N-(hydroxymethyl)acetamide (N-hydroxymethylchloroacetamide) may be used as a reagent in the synthesis of 1-(aminomethyl)-2-methoxynaphthalene hydrochloride and as a amidomethylating reagent for N,N-dialkylanilines (Tscherniac-Einhorn reaction).

General Description

2-Chloro-N-(hydroxymethyl)acetamide (N-methylolchloracetamide) is a N-hydroxymethyl derivative of chloroacetamide. One of the method reported for its synthesis is by the reaction of 2-chloracetamide with formaldehyde. It has been reported to be a formaldehyde releaser and an infrequent sensitizer to formaldehyde contact allergy. Influence of short and prolonged exposure of 2-chloro-N-(hydroxymethyl)acetamide (as formaldehyde donor/releaser) on lymph node responses has been investigated. It has high biocide action and is utilized as preservative.

InChI:InChI=1/C3H6ClNO2/c4-1-3(7)5-2-6/h6H,1-2H2,(H,5,7)

Upstream product

• 50-00-0 formaldehyd 
• 79-07-2 Chloroacetamide 

Downstream Products

• 117885-63-9 {4-[(2-chloro-acetylamino)-methyl]-phenyl}-acetic acid 
• 345991-81-3 5-[(chloroacetyl-amino)-methyl]-furan-2-carboxylic acid methyl ester 
• 82252-06-0 benzoyloxy-(2-chloro-acetylamino)-methane 
• 70110-32-6 N-(2,4-dimethylbenzyl)-2-chloroacetamide 
• 93648-16-9 1,5-bis-[(2-chloro-acetylamino)-methyl]-2,4-dimethyl-benzene 
• 102677-62-3 chloro-acetic acid-(4-acetylamino-benzylamide) 
• 718-15-0 3-[(2-chloro-acetylamino)-methyl]-benzoic acid 
• 2564-06-9 N-benzyl-2-chloroacetamide 
• 107553-68-4 5-(N-Chloroacetylamino)methyl-2-acetylthiophene 
• 107553-67-3 5-(N-Chloroacetylamino)methyl-2-acetylthiophene 
• 102677-66-7 N-(5-Acetylamino-2-methoxy-benzyl)-2-chloro-acetamide 
• 102677-64-5 N-(5-Acetylamino-2-methyl-benzyl)-2-chloro-acetamide 
• 85297-70-7 2,3-Dichloro-4-[(3'-chloroacetamidomethyl-4'-hydroxy)benzoyl]phenoxyethanol 
• 185455-01-0 2-Chloro-N-{3-[(2-chloro-acetylamino)-methyl]-2-methoxy-5-nitro-benzyl}-acetamide 

Relevant articles and documents

FUNGICIDAL PENFLUFEN MIXTURES

The invention relates to mixtures comprising penflufen, to the use of these mixtures for protecting industrial materials and to a method for treating industrial materials with the penflufen mixtures.

Bromonitrothienyldioxanes

The invention relates to novel 5-bromo-5-nitro-2-thienyl-1,3-dioxanes of the formula (I) in which R1, R2 and R3 are as defined in the description are highly suitable for use as biocides for protecting plants and industrial materials.

O-aryl dithiazole dioxides

The invention relates to new O-aryldithiazole dioxides, to two processes for their preparation, and to their use as pesticides in crop protection and in the protection of materials.