58469-06-0

Usage

Uses

Used in Pharmaceutical Research:
N-(2-Hydroxy-4-Methoxyphenyl)acetamide is used as a building block in the synthesis of biologically active molecules for pharmaceutical research. Its structural features allow for the development of compounds with potential therapeutic applications.
Used in Organic Synthesis:
In the field of organic synthesis, N-(2-Hydroxy-4-Methoxyphenyl)acetamide is utilized as a key intermediate, facilitating the creation of a variety of chemical compounds with diverse applications.
Used in Skincare Products:
N-(2-Hydroxy-4-Methoxyphenyl)acetamide is considered for use in skincare products due to its antioxidant properties, which may contribute to the protection of the skin from oxidative stress and contribute to anti-aging effects.
Used in Anti-Inflammatory and Analgesic Applications:
N-(2-Hydroxy-4-Methoxyphenyl)acetaMide is studied for its potential anti-inflammatory and analgesic effects, suggesting that it could be used in the development of medications aimed at reducing inflammation and pain.
If further applications are identified in different industries, they can be listed as follows:
Used in [Application Industry]:
N-(2-Hydroxy-4-Methoxyphenyl)acetamide is used as [application type] for [application reason].

Upstream product

• 23999-64-6 6-methoxy-2-methyl-benzoxazole 
• 51-66-1 4-methoxyacetanilide 
• 40925-70-0 2-amino-5-methoxyphenol 
• 108-24-7 acetic anhydride 
• 7647-01-0 hydrogenchloride 
• 704-14-3 3-methoxy-6-nitro-phenol 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 

Downstream Products

• 1076242-70-0 N-[2-({(2S)-3-[4-(4-fluorobenzyl)-2-oxo-piperazin-1-yl]-2-hydroxypropyl}oxy)-4-hydroxyphenyl]acetamide trifluoroacetate 
• 644968-75-2 N-(2-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-hydroxyphenyl)acetamide 
• 644968-71-8 N-(2-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-methoxyphenyl)acetamide 
• 1076242-68-6 N-[2-({(2S)-3-[4-(4-fluorobenzyl)-2-oxo-piperazin-1-yl]-2-hydroxypropyl}oxy)-4-methoxyphenyl]acetamide trifluoroacetate 
• 384346-20-7 N-[4-Methoxy-2-(2-oxiranylmethoxy)phenyl]acetamide 
• 460047-81-8 N-{4-methoxy-2-[(2S)-oxiran-2-ylmethoxy]phenyl}acetamide 

Relevant academic research and scientific papers

Ruthenium(II)-Catalyzed Regioselective C-8 Hydroxylation of 1,2,3,4-Tetrahydroquinolines

Ru(II)-catalyzed chelation-assisted highly regioselective C8-hydroxylation of 1,2,3,4-tretrahydroquinolines has been developed. Various 1,2,3,4-tetrahydroquinolines underwent smooth C8-H hydroxylation with cheap and safe K2S2O8 as the oxidant and oxygen source to furnish the corresponding products in good to excellent yields with high tolerance of the functional groups. The choice of a readily installable and removable N-pyrimidyl directing group is the key to catalysis. Mechanistic studies suggest the involvement of a six-membered ruthenacycle intermediate in the catalytic cycle. The method can also be extended to the direct hydroxylation of other (hetero)arene C-H bonds.

Spirocyclic compounds, potent CCR1 antagonists

Conformationally constrained spirocycles (17-23) and (31-36) were synthesised. In vitro data revealed that these compounds are CCR1 antagonists with sub-nanomolar potency. In a functional assay 22, 23 and 36 inhibited CCR1 mediated chemotaxis with an ICs

NOVEL COMPOUNDS

The invention provides compounds of formula (I) wherein m, R1, n, R2, q, X, Y, Z, t, R3, R4, R5, R6, R7 and R8 are as defined in the specification, processes for their

Novel compounds for use in weight loss and appetite suppression in humans

Phenolic compounds with a phenolic molecule to which are covalently linked an oxygen-containing group, a nitrogen or another oxygen containing group, and a C1-C4 alkoxy group, obtainable from monocotyledonous plants, or by chemical synthesis, have been found to act as weight loss agents, appetite suppressants, mood enhancers and adjunctive therapy for arthritis, sleep apnea, fibromyalgia, diabetes and hyperglycemia. Additional chemical compounds of the present invention may include benzoxazinoids-cyclic hydroxyamic acids, lactams, and corresponding glucosides, which may serve as precursors to phenolic compounds. The phenolic compounds and precursors of phenolic compounds of the present invention, at concentrations suitable for human therapeutic use, may be obtained from monocotyledonous plants such as corn in their early growth states which are timely harvested for optimum yield.

NOVEL TRICYCLIC SPIROPIPERIDINES OR SPIROPYRROLIDINES

The invention provides compounds of formula (I) wherein m, R1, n, R2, q, X, Y, Z, R3, R4, R5, R6, R7, R8, t and R9 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

Introduction of a hydroxy group at the para position and N-iodophenylation of N-arylamides using phenyliodine(III) bis(trifluoroacetate)

The reaction of anilides with phenyliodine(III) bis(trifluoroacetate) (PIFA) in trifluoroacetic acid (TFA), TFA-CHCl3, or hexafluoroisopropyl alcohol (HFIP) is described. When the acyl group of the anilide is highly electronegative, such as trifluoroacetyl, or the phenyl group is substituted with an electron-withdrawing group, the 4-iodophenyl group is transferred from PIFA to the amide nitrogen to afford acetyldiarylamines. On the other hand, when the acyl group contains an electron-donating function, such as 4-methoxyphenyl, or the phenyl group is substituted with an electron-donating group, a trifluoroacetoxy group is transferred to the para position of the anilide aromatic ring. This group is hydrolyzed during workup to produce the corresponding phenol.