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7-benzyl-1-methyl-3-(2-methylpropyl)-3,7-dihydro-1H-purine-2,6-dione is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

58481-23-5

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58481-23-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 58481-23-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,8,4,8 and 1 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 58481-23:
(7*5)+(6*8)+(5*4)+(4*8)+(3*1)+(2*2)+(1*3)=145
145 % 10 = 5
So 58481-23-5 is a valid CAS Registry Number.

58481-23-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 7-benzyl-1-methyl-3-(2-methylpropyl)purine-2,6-dione

1.2 Other means of identification

Product number -
Other names Xanthine,7-benzyl-3-isobutyl-1-methyl

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:58481-23-5 SDS

58481-23-5Relevant academic research and scientific papers

Design and synthesis of xanthine analogues as potent and selective PDE5 inhibitors

Wang, Yuguang,Chackalamannil, Samuel,Hu, Zhiyong,Boyle, Craig D.,Lankin, Claire M.,Xia, Yan,Xu, Ruo,Asberom, Theodros,Pissarnitski, Dmitri,Stamford, Andrew W.,Greenlee, William J.,Skell, Jeffrey,Kurowski, Stanley,Vemulapalli, Subbarao,Palamanda, Jairam,Chintala, Madhu,Wu, Ping,Myers, Joyce,Wang, Peng

, p. 3149 - 3152 (2007/10/03)

We have discovered potent and selective xanthine PDE5 inhibitors. Compound 25 (PDE5 IC50=0.6 nM, PDE6/PDE5=101) demonstrated similar functional efficacy and PK profile to Sildenafil (PDE5 IC50=3.5 nM, PDE6/PDE5=7).

Structure-activity relationships in a series of xanthine derivatives with antibronchoconstrictory and bronchodilatory activities

Merlos,Gomez,Vericat,Bartroli,Garcia-Rafanell,Forn

, p. 653 - 658 (2007/10/02)

Thirty-one 1,3,7,8-substituted xanthine derivatives have been synthesized and evaluated for bronchodilator and anti-bronchoconstrictory activities in in vitro tracheal relaxation and in vivo bronchospasm inhibition models. Activity tests have been complemented with phosphodiesterase inhibition and toxicological data. Structure-activity relationships are discussed. Compound 21 (1,3-diisobutyl-8-methylxanthine) has been selected for further pharmacological development because of its good activity profile and favourable therapeutic index, which is 14- and 38-fold greater than that of theophylline and IBMX, respectively.

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