78033-18-8

Basic information

• Product Name: 4,5-DIAMINO-3-ISOBUTYL-1-METHYLPYRIMIDINE-2,6-DIONE
• Synonyms: 5,6-DiaMino-3-Methyl-1-(2-Methylpropyl)-2,4(1H,3H)-pyriMidinedione
• CAS NO: 78033-18-8
• Molecular Formula: C₉H₁₆N₄O₂
• Molecular Weight: 212.25
• Product Categories: Nucleotides and Nucleosides;Bases & Related Reagents;Intermediates;Nucleotides;Amines
• Mol File: 78033-18-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 180-183°C
• Boiling Point: 288.4°C at 760 mmHg
• Flash Point: 128.2°C
• Appearance: /
• Density: 1.199g/cm³
• Vapor Pressure: 0.00234mmHg at 25°C
• Refractive Index: 1.543
• Storage Temp.: Refrigerator
• Stability: Protect From Air
• CAS DataBase Reference: 4,5-DIAMINO-3-ISOBUTYL-1-METHYLPYRIMIDINE-2,6-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-DIAMINO-3-ISOBUTYL-1-METHYLPYRIMIDINE-2,6-DIONE(78033-18-8)
• EPA Substance Registry System: 4,5-DIAMINO-3-ISOBUTYL-1-METHYLPYRIMIDINE-2,6-DIONE(78033-18-8)

Safety Data

• Hazardous Substances Data: 78033-18-8(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Crystals

Uses

4,5-Diamino-3-isobutyl-1-methylpyrimidine-2,6-dione (cas# 78033-18-8) is a compound useful in organic synthesis.

InChI:InChI=1/C9H16N4O2/c1-5(2)4-13-7(11)6(10)8(14)12(3)9(13)15/h5H,4,10-11H2,1-3H3

Upstream product

• 38014-54-9 1-isobutyl-3-methyl-urea 
• 58481-39-3 6-amino-1-isobutyl-3-methyl-1H-pyrimidine-2,4-dione 
• 54052-67-4 1-isobutyl-3-methyl-5-nitroso-6-amino uracil 

Downstream Products

• 28822-58-4 3,7-dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione 
• 90749-80-7 N-(6-Amino-1-isobutyl-3-methyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-4-methoxy-butyramide 
• 132560-08-8 3-Isobutyl-1-methyl-8-propyl-3,7-dihydro-purine-2,6-dione 
• 503809-63-0 8-(2-isobutoxy-phenyl)-3-isobutyl-1-methyl-3,7-dihydro-purine-2,6-dione 
• 132560-18-0 7-(3,3-Diethoxy-propyl)-3-isobutyl-1-methyl-3,7-dihydro-purine-2,6-dione 
• 132560-21-5 3-(3-Isobutyl-1-methyl-2,6-dioxo-1,2,3,6-tetrahydro-purin-7-yl)-propionic acid 
• 132560-17-9 7-Dimethoxymethyl-3-isobutyl-1-methyl-3,7-dihydro-purine-2,6-dione 
• 132560-20-4 7-(2,3-Dihydroxy-propyl)-3-isobutyl-1-methyl-3,7-dihydro-purine-2,6-dione 
• 68006-09-7 (3-isobutyl-1-methyl-2,6-dioxo-1,2,3,6-tetrahydro-purin-7-yl)-acetic acid 
• 58481-23-5 7-Benzyl-3-isobutyl-1-methylxanthine 
• 58481-29-1 7-(4-chloro-benzyl)-3-isobutyl-1-methyl-3,7-dihydro-purine-2,6-dione 
• 90749-45-4 1,7-dimethyl-3-isobutyl-8-[3-(4-di[para-fluorophenyl]-methylpiperazinyl)propyl]xanthine 
• 90749-43-2 8-(2-{4-[Bis-(4-fluoro-phenyl)-methyl]-piperazin-1-yl}-ethyl)-3-isobutyl-1,7-dimethyl-3,7-dihydro-purine-2,6-dione 
• 110480-56-3 8-(3-{[2-(Benzhydryl-ethyl-amino)-ethyl]-ethyl-amino}-propyl)-3-isobutyl-1,7-dimethyl-3,7-dihydro-purine-2,6-dione 

Relevant articles and documents

Structure-activity relationships in a series of xanthine derivatives with antibronchoconstrictory and bronchodilatory activities

Thirty-one 1,3,7,8-substituted xanthine derivatives have been synthesized and evaluated for bronchodilator and anti-bronchoconstrictory activities in in vitro tracheal relaxation and in vivo bronchospasm inhibition models. Activity tests have been complemented with phosphodiesterase inhibition and toxicological data. Structure-activity relationships are discussed. Compound 21 (1,3-diisobutyl-8-methylxanthine) has been selected for further pharmacological development because of its good activity profile and favourable therapeutic index, which is 14- and 38-fold greater than that of theophylline and IBMX, respectively.

Inhibition of separated forms of cyclic nucleotide phosphodiesterase from pig coronary arteries by 1,3-disubstituted and 1,3,8-trisubstituted xanthines

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