58484-76-7Relevant academic research and scientific papers
N-hydroxy-substituted 2-aryl acetamide analogs: A novel class of HIV-1 integrase inhibitors
Debnath, Utsab,Kumar, Prachi,Agarwal, Aakanksha,Kesharwani, Ajay,Gupta, Satish K.,Katti, Seturam B.
, p. 527 - 534 (2017/09/14)
An in silico method has been used to discover N-hydroxy-substituted 2-aryl acetamide analogs as a new class of HIV-1 integrase inhibitors. Based on the molecular requirements of the binding pocket of catalytic active site, two molecules (compounds 2 and 4
A facile synthesis of p- and m-(amidinomethyl)phenyl esters derived from amino acid and tryptic hydrolysis of these synthetic inverse substrates
Sekizaki, Haruo,Itoh, Kunihiko,Shibuya, Akiyoshi,Toyota, Eiko,Tanizawa, Kazutaka
, p. 1514 - 1517 (2008/03/12)
A facile synthetic method for p- and m-(amidinomethyl)phenyl esters derived from a variety of amino acids is presented. We analyzed the kinetic behavior of trypsin towards these synthetic esters, which are inverse substrates. The substituent (meta- and para-isomers) and isosteric effects of (amidinomethyl)phenyl esters are discussed.
New 1,2,4-oxadiazole derivatives: Synthesis and adrenergic receptors binding studies
Brizzi,Brufani,Filocamo,Bruni,Fiaschi
, p. 953 - 966 (2007/10/02)
In order to obtain derivatives with simultaneous α- and β-adrenergic blocking activity, compounds having the phenoxypropanolaminic structure of β-adrenergic blockers have been synthesised, as well as 1,2,4-oxadiazole moiety, which could imitate the imidaz
