58486-88-7

Upstream product

• 182884-62-4 (Z)-2-bromo-3-(p-tolyl)propenoic acid 
• 1670-14-0 benzamidine monohydrochloride 
• 623-33-6 glycine ethyl ester hydrochloride 
• 5873-90-5 methyl benzimidate hydrochloride 
• 104-87-0 4-methyl-benzaldehyde 
• 459-73-4 GlyOEt*HCl 
• 7471-86-5 methyl benzimidate 
• 82309-33-9 4-(4-methylbenzylidene)-2-phenyloxazol-5-one 

Downstream Products

• 133528-45-7 (4R,5R)-7-Phenyl-4-p-tolyl-3-(2,4,6-trimethyl-phenyl)-1-oxa-2,6,8-triaza-spiro[4.4]nona-2,6-dien-9-one 
• 133528-48-0 (4R,5R)-3-(2,6-Dichloro-phenyl)-7-phenyl-4-p-tolyl-1-oxa-2,6,8-triaza-spiro[4.4]nona-2,6-dien-9-one 
• 74084-19-8 N-[1-Carbamoyl-2-(4-chloro-phenyl)-ethyl]-benzamide 
• 74084-18-7 2-(benzoylamino)-3-(4-methylbenzene)propanamide 
• 74164-07-1 N-benzoyl-2-chloro-phenylalanine 

Relevant academic research and scientific papers

Formation and thermal rearrangement of 4,4'-diarylmethyl- 2,2'- diaryl-4,4'-biimidazolin-5,5'-diones

Recrystallisation of 4-arylmethyl-2-aryl-2-imidazolin-5-ones from ethanol results in the formation of 4,4'-diarylmethyl-2,2'-diaryl-4,4'-biimidazolin-5,5'-diones. These products undergo a McLafferty type rearrangement to give one molecule of 4-arylmethyl-2-aryl-2-imidazolin-5-one and one molecule of 4-arylidene-2-aryl-2-imidazolin-5-one under mass spectrometric conditions. The same rearrangement is also found to occur on heating the compounds just above their melting points.

A practical and efficient synthesis of 2,5-disubstituted-3,5-dihydro- imidazol-4-ones from oxazolones

An alternative procedure for the synthesis of 2,5-disubstituted-3,5- dihydro-imidazol-4-ones from substituted oxazolones was evaluated. The initial oxazolone ring-opening reaction was examined with a variety of ammonia source compounds followed by the sub

Extension of a cascade reaction: Microwave-assisted synthesis of the GFP chromophore derivatives

(Chemical Equation Presented) A facile microwave-assisted synthesis of imidazol-5(4H)-one derivatives is accomplished via reactions of 4-arylmethylene-2-phenyloxazol-5(4H)-ones with urea (or ammonium acetate) in ethylene glycol. The cascade reaction is simple to perform and occurs under mild conditions with broad scope of applicability.

Simple and efficient copper-catalyzed approach to 2,4-disubstituted imidazolones

(Figure Presented) Some imidazolone derivatives are biological and pharmaceutical active molecules and the chromophores of the fluorescent proteins. In this communication, a simple and efficient approach to 4-arylidene-2-alkyl-4,5-dihydro-1H-imidazol-5-ones (2,4-disubstituted imidazolones) has been developed, and the protocol uses readily available 2-bromo-3-alkylacrylic acids and amidines as the starting materials without addition of any ligand or additive. The reactions were performed under mild conditions. Therefore, the present method will be of wide application in organic chemistry and medicinal chemistry.

Synthesis of Acylamino Acid Amides and Acylamino Acids via 2,4-Disubstituted 2-Imidazolin-5-ones

Unsaturated 2,4-disubstituted 2-imidazolin-5-ones (I) have been reduced with a mixture of hydriodic acid and red phosphorus in the presence of acetic anhydride to give the saturated 2,4-disubstituted 2-imidazolin-5-ones (II) which have been hydrolysed to acylamino acid amides (III) and acylamino acids (IV) with sodium hydroxide solution under different conditions.In all six acylamino acid amides (23 - 51percent yields) and four acylamino acids (26 - 65percent yields) have been prepared.One saturated 2-imidazolin-5-one, namely 2-phenyl-4-benzyl-2-imidazolin-5-one has been isolated from the reaction in 40percent yield and identified.