58487-95-9

Upstream product

• 161911-81-5 ethyl 2-(4-chlorophenyl)hydrazono-3-oxobutyrate 

Downstream Products

• 162713-10-2 ethyl 3-(4-chlorophenyl)-3a-methyl-5-phenyl-3,3a,4,11-tetrahydro-3H-<1,2,4>-triazolo<4,3-a><1,5>benzodiazepine-1-carboxylate 
• 1246267-22-0 C₃₀H₁₉ClN₆O₃S 
• 1397711-07-7 {2-[1-(4-chlorophenyl)-3-ethoxycarbonyl-4,5-dihydro-1H-pyrazol-5-yl]-5,10,15,20-tetraphenylporphyrinato}zinc(II) 
• 1397711-13-5 {2-[1-(4-chlorophenyl)-3-ethoxycarbonyl-1H-pyrazol-5-yl]-5,10,15,20-tetraphenylporphyrinato}zinc(II) 
• 1397711-31-7 {2-[3-carboxy-1-(4-chlorophenyl)-1H-pyrazol-5-yl]-5,10,15,20-tetraphenylporphyrinato}zinc(II) 
• 1337534-99-2 ethyl 4-(4-chlorophenyl)-5-((1-(4-(N,N-dibenzylsulfamoyl)phenyl)ethylidene)hydrazono)-4,5-dihydro-1,3,4-thiadiazole-2-carboxylate 

Relevant academic research and scientific papers

S1P3 RECEPTOR ANTAGONIST

The present invention relates to a medicine, and more particularly to novel arylamidrazone derivatives having an antagonistic action against S1P3 receptors and a medicine containing thereof as an active ingredient. The present invention provides an arylamidrazone derivative represented by' the following formula (1) or a pharmaceutically acceptable salt thereof: wherein R1 represents a C2-C8 alkyl group which maybe substituted, a phenyl group which maybe substituted, an aromatic heterocyclic group which may be substituted, a C2-C8 alkoxy group which may be substituted, or -NR4R5 (wherein R4 and R5, which are identical or different, each represent a hydrogen atom or a lower alkyl group which may be substituted, or R4 and R5 may be joined with the adjacent nitrogen atom to form a nitrogen-containing heterocyclic ring which may be substituted); R2 and R3, which are identical or different, each represent a hydrogen atom, a halogen atom, a halo-lower alkyl group, a lower alkyl group, a lower alkynyl group, a lower alkoxy group, a cyano group, a lower alkanoyl group or a lower alkylsulfonyl group; A represents a benzene ring or a heterocyclic ring; D represents a single bond or methylene; m represents an integer from 1 to 3, and n represents an integer from 1 to 5 (with the proviso that the case where R1 is an ethoxy group, R2 is a 2,4-dichloro group, R3 is a hydrogen atom, A is a benzene ring, and D is methylene; and the case where R1 is an ethoxy group, R2 is a 2,4-dichloro group, R3 is a hydrogen atom, a 2-methyl group, a 4-methyl group, a 4-methoxy group or a 4-ethoxy group, A is a benzene ring, and D is a single bond, are excluded).

Syntheses and antiinflammatory actions of 4,5,6,7-tetrahydroindazole-5-carboxylic acids.

A novel series of 1-aryl-4,5,6,7-tetrahydro-1H-indazole-5-carboxylic acids and 2-aryl-4,5,6,7-tetrahydro-2H-indazole-5-carboxylic acids were synthesized via condensation between a phenylhydrazine and a 2-(hydroxymethylene)cyclohexanone-4-carboxylate, and