5849-03-6

Basic information

• Product Name: 1,3-Dithiane, 2-methyl-2-(phenylmethyl)-
• CAS NO: 5849-03-6
• Molecular Formula: C12H16S2
• Molecular Weight: 224.391
• Mol File: 5849-03-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1,3-Dithiane, 2-methyl-2-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dithiane, 2-methyl-2-(phenylmethyl)-(5849-03-6)
• EPA Substance Registry System: 1,3-Dithiane, 2-methyl-2-(phenylmethyl)-(5849-03-6)

Safety Data

• Hazardous Substances Data: 5849-03-6(Hazardous Substances Data)

Usage

Physical state

Colorless liquid

Odor

Slightly unpleasant

Usage

Reagent in organic chemistry

Application

Synthesis of other organic compounds

Preparation

Used in the preparation of various functionalized molecules

Versatility

Can undergo a range of reactions to produce different compounds

Importance

Valuable reagent in the field of organic chemistry

Upstream product

• 109-80-8 1.3-propanedithiol 
• 673-32-5 1-Phenylprop-1-yne 
• 71094-32-1 2,2-diethoxy-1-phenylpropane 
• 6413-86-1 2-benzyl-2-methyl-[1,3]dioxane 
• 103-79-7 1-phenyl-acetone 
• 15681-48-8 lithium dimethylcuprate 

Downstream Products

• 103-79-7 1-phenyl-acetone 

Relevant articles and documents

Mild Deprotection of Dithioacetals by TMSCl/NaI Association in CH3CN

A mild process using a combination of TMSCl and NaI in acetonitrile is used to regenerate carbonyl compounds from a variety of dithiane and dithiolane derivatives. This easy to handle and inexpensive protocol is also efficient to deprotect oxygenated and mixed acetals as 1,3-dioxanes, 1,3-dioxolanes and 1,3-oxathianes quantitatively. As a possible extension of this method, it was also shown that nitrogenated substrates such as hydrazones, N-tosylhydrazones, and ketimines reacted well under these conditions to give the expected ketones in high yields. The methodology proposed herein is a good alternative to the existing methods since it does not use metals, oxidants, reducing agents, acidic or basic media, and keto-products were obtained in high to excellent yields.

Chemoselective dithioacetalization and oxathioacetalization of carbonyl compounds using alumina sulfuric acid as catalyst

Carbonyl compounds have been successfully converted into their corresponding dithiolane, dithiane, and oxathiolane derivatives using a catalytic amount of alumina sulfuric acid (Al2O3-SO3H) with excellent yields at room temperature in short reaction times under mild conditions. This simple method is a highly chemoselective procedure for protection of aldehydes in the presence of ketones, and the heterogeneous catalyst can be recovered and reused several times without any loss of its activity. Copyright Taylor & Francis Group, LLC.

2,4,4,6-Tetrabromo-2,5-cyclohexadienone (TABCO), N-bromosuccinimide (NBS) and bromine as efficient catalysts for dithioacetalization and oxathioacetalization of carbonyl compounds and transdithioacetalization reactions

The use of 2,4,4,6-tetrabromo-2,5-cyclohexadienone (TABCO), N-bromosuccinimide (NBS), and bromine as efficient catalysts for conversion of carbonyl compounds to their cyclic and acyclic dithioacetals and 1,3-oxathiolanes under mild reaction conditions are described. These catalysts are also used for efficient transdithioacetalization of acetals, diacetals, ketals, acylals, enamines, hydrazones, and oximes with high yields in the presence of thiols.