58502-70-8Relevant academic research and scientific papers
Discovery of 4-amino-5,6-biaryl-furo[2,3-d]pyrimidines as inhibitors of Lck: Development of an expedient and divergent synthetic route and preliminary SAR
DiMauro, Erin F.,Newcomb, John,Nunes, Joseph J.,Bemis, Jean E.,Boucher, Christina,Buchanan, John L.,Buckner, William H.,Cheng, Alan,Faust, Theodore,Hsieh, Faye,Huang, Xin,Lee, Josie H.,Marshall, Teresa L.,Martin, Matthew W.,McGowan, David C.,Schneider, Stephen,Turci, Susan M.,White, Ryan D.,Zhu, Xiaotian
, p. 2305 - 2309 (2007)
4-Amino-5,6-biaryl-furo[2,3-d]pyrimidines were identified as potent non-selective inhibitors of Lck. A novel, divergent, and practical synthetic route was developed to access derivatives from bifunctional intermediates. Lead optimization was guided by X-r
