58526-50-4Relevant articles and documents
Synthesis of 9-cis-retinoic acid and C-20-[3H3C]-9-cis-retinoic acid with high specific activity
Tadikonda, Praveen K.,Lacy, James M.,Rigdon, Michael G.,Deluca, Hector F.
, p. 1 - 10 (2007/10/03)
The synthesis of 9-cis-retinoic acid starting from 2,2,6-trimethylcyclohexanone is described. The same methodology was extended for the synthesis of deuterium and tritium labeled 9-cis-retinoic acid with high specific activity (73 Ci/mmol). In this methodology, a Grignard reaction was utilized for introducing three tritium atoms simultaneously in the final synthetic steps.
Assignment of 1H and 13C NMR Spectra of Retinoic Acid Ester Isomers Observed in the Long-Wavelength UV-Induced Photostationary State
Curley, Robert W.,Fowble, John W.
, p. 707 - 709 (2007/10/02)
1H and 13C chemical shift assignments, obtained with the aid of two-dimensional hetenuclear shift correlation and double-quantum coherence 13C-INADEQUATE experiments, are reported for four retinoic acid ester isomers observed at the photostationary state.Also detailed are 1H assignments for three additional isomers obtained in insufficient amounts for 13C measurements.KEY WORDS - Retionic acid esters Isomer identification 1H-13C correlation spectra 13C-INADEQUATE experiment
NEW MASKED BUILDING BLOCK FOR ISOPRENOID POLYENE CHAIN SYNTHESIS
Mandai, T.,Iuchi, Y.,Suzuki, K.,Kawada, M.,Otera, J.
, p. 4721 - 4724 (2007/10/02)
The new building blocks 2, 3, and 4 have been effectively synthesized starting from 2-hydroxymethyl-4-phenylthio-1-butene (1a).A convenient synthesis of retinoic acid methyl ester (9) using 2 is also described.