58546-27-3Relevant academic research and scientific papers
Nitration of camptothecin with various inorganic nitrate salts in concentrated sulfuric acid: A new preparation of anticancer drug 9- nitrocamptothecin
Cao, Zhisong,Armstrong, Kim,Shaw, Marcus,Petry, Eddie,Harris, Nick
, p. 1724 - 1730 (1998)
The nitration reactions of camptothecin (1) with 19 commonly used inorganic nitrate salts and a combination of two or more different nitrate salts in concentrated sulfuric acid are discussed. A new preparation of a promising anticancer drug 9-nitro-camptothecin (4) with a combination of potassium nitrate and thallium(I) nitrate as the nitrating reagents in concentrated sulfuric acid is described.
Urea-mediated regioselective nitration of (20s)-camptothecin
Puri,Handa,Suri,Qazi
, p. 3443 - 3448 (2004)
A facile and efficient procedure for the regioselective nitration of (20S) camptothecin, using urea mediated reagent system under relatively mild experimental conditions, yielding promising anticancer drug 9-nitro-(20S)- camptothecin in 40% yield with purity of 94.5% (on HPLC) is being reported.
Synthesis and antitumor activity of 20(S)-camptothecin derivatives: A-ring modified and 7,10-disubstituted camptothecins
Sawada,Matsuoka,Nokata,Nagata,Furuta,Yokokura,Miyasaka
, p. 3183 - 3188 (2007/10/02)
20(S)-Camptothecin derivatives having nitro, amino, chloro, bromo, hydroxyl and methoxyl groups in the A-ring were synthesized. B-Ring hydrogenated camptothecin (2a) was converted into 10-hydroxycamptothecin (6e) by treatment with lead tetraacetate in trifluoroacetic acid. 10-Substituted derivatives (6) were obtained by a photoreaction of N-oxides (9). The cytotoxicity of the A-ring modified camptothecins was evaluated against KB cells in vitro and leukemia L1210 in mice. 7-Ethyl-10-hydroxycamptothecin (6i) was identified as a potential derivative for further modification.
