585544-16-7Relevant academic research and scientific papers
Kinase array design, back to front: Biaryl amides
Baldwin, Ian,Bamborough, Paul,Haslam, Claudine G.,Hunjan, Suchete S.,Longstaff, Tim,Mooney, Christopher J.,Patel, Shila,Quinn, Jo,Somers, Don O.
, p. 5285 - 5289 (2008)
New kinase inhibitors can be found by synthesis of targeted arrays of compounds designed using system-based knowledge as well as through screening focused or diverse compounds. Most array strategies aim to add functionality to a fragment that binds in the
FUSED HETEROARYL DERIVATIVES FOR USE AS P38 KINASE INHIBITORS IN THE TREATMENT OF I.A. RHEUMATOID ARTHRISTIS
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Page/Page column 31, (2010/11/30)
Compounds of formula (I): wherein A is a 5-membered heteroaryl ring are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38, such as rheumatoid arthritis.
HETEROARYL SUBSTITUTED BIPHENYL DERIVATIVES AS P38 KINASE INHIBITORS
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Page/Page column 27, (2010/02/07)
Compounds of formula (I) are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38.
