58558-08-0

Basic information

• Product Name: Saikosaponin B1
• Synonyms: SAIKOSAPONIN B1;(3b,4a,16b)-16,23,28-trihydroxyoleana-11,13(18)-dien-3-yl-6-deoxy-3-o-beta-d-glucopyranosyl-beta-d-galactopyranoside;Sailkosaponins b1;[(4R)-16β,23,28-Trihydroxyoleana-11,13(18)-dien-3β-yl]3-O-(β-D-glucopyranosyl)-6-deoxy-β-D-galactopyranoside;SaikosaponinB
• CAS NO: 58558-08-0
• Molecular Formula: C₄₂H₆₈O₁₃
• Molecular Weight: 780.98
• Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 58558-08-0.mol

Chemical Properties

• Melting Point: 235-238°C
• Boiling Point: 909.9 °C at 760 mmHg
• Flash Point: 504.1 °C
• Appearance: /
• Density: 1.35 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.619
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 12.83±0.70(Predicted)
• CAS DataBase Reference: Saikosaponin B1(CAS DataBase Reference)
• NIST Chemistry Reference: Saikosaponin B1(58558-08-0)
• EPA Substance Registry System: Saikosaponin B1(58558-08-0)

Safety Data

• Hazardous Substances Data: 58558-08-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Saikosaponin B1 is used as a therapeutic agent for its anti-inflammatory properties, helping to reduce inflammation and alleviate pain in various conditions. Its immunomodulatory effects also make it a potential candidate for the treatment of autoimmune diseases and infections.
Used in Antiviral Applications:
Saikosaponin B1 is used as an antiviral agent, demonstrating the ability to inhibit viral replication and reduce the severity of viral infections. This makes it a valuable compound in the development of antiviral medications and treatments.
Used in Cancer Therapy:
Saikosaponin B1 is used as an anti-cancer agent, showing potential in inhibiting the growth and proliferation of cancer cells. Its ability to modulate various signaling pathways involved in cancer progression makes it a promising candidate for the development of novel cancer therapies.
Used in Drug Delivery Systems:
Saikosaponin B1 is used as a component in drug delivery systems to enhance the bioavailability and therapeutic efficacy of other drugs. Its natural properties may allow for improved targeting of specific cells or tissues, increasing the effectiveness of treatments while reducing side effects.

InChI:InChI=1/C42H68O13/c1-21-29(47)34(55-35-32(50)31(49)30(48)24(18-43)53-35)33(51)36(52-21)54-28-11-12-38(4)25(39(28,5)19-44)10-13-40(6)26(38)9-8-22-23-16-37(2,3)14-15-42(23,20-45)27(46)17-41(22,40)7/h8-9,21,24-36,43-51H,10-20H2,1-7H3/t21-,24-,25-,26-,27+,28+,29+,30-,31+,32-,33-,34+,35+,36+,38+,39+,40-,41-,42-/m1/s1

Upstream product

• 20736-09-8 saikosaponin A 

Downstream Products

• 99365-21-6 prosaikosaponin D 
• 5092-09-1 3β,16β,23,28-tetrahydroxyolean-11,13(18)-diene 

Relevant articles and documents

Determination of saikosaponin derivatives in Radix bupleuri and in pharmaceuticals of the Chinese multiherb remedy Xiaochaihu-tang using liquid chromatographic tandem mass spectrometry

Saikosaponins are bioactive oleanane saponins derived from the Chinese medicinal herb Radix bupleuri ("chaihu" in Chinese). An LC-MS/MS-hased method has been developed for characterization and quantification of 15 saikosaponin derivatives (saikosaponin a, saikosaponin b1, saikosaponin g, saikogenin A, saikogenin H, saikosaponin C2, saikosaponin B2, saikosaponin i, prosaikogenin C2, prosaikogenin B2, saikogenin C, saikogenin B, saikosaponin d, saikosaponin b2, and saikogenin D) in one chromatographic run. Optimization of the ionization process was performed with electrospray and atmospheric pressure chemical ionization techniques in both positive and negative ion modes. Negative ion ESI was adopted for generation of the precursor deprotonated molecules to achieve the best ionization sensitivity for the analytes. In addition, the most abundant fragment ion was chosen for each analyte to give the best CID sensitivity. Because some of the saponin derivatives are isomeric, complete resolution for the whole analytes was achieved both chromatographically and mass spectroscopically. Furthermore, optimal internal standard was successfully discovered for determination of the analytes by making use of a combinatorial chemistry approach. Good linearity over the range ～1.65 or 4.98 to 1200 ng/mL for the analytes was observed. The intraday accuracy and precision at nominal low, intermediate, and high concentration varied between 0.8 and 11.8% and between 80 and 116%, respectively, whereas those for interday assay were between 1.1 and 15.5% and between 86 and 119%, respectively. The lower limits of quantitation for the test compounds were ～16.5 to 49.4 pg on-column. The new method offered higher sensitivity and greater specificity than previously reported LC methods. After the validation, the applicability of the method for determination of these chemicals present in a variety of crude chaihu roots and in different brands of the Chinese multiherb remedy Xiaochaihu-tang (or Shosaiko-to) extract granules has been demonstrated. The sensitivity and specificity of the technique will be the basis of a method for the accurate quantification of the saikosaponin derivatives in biomatrixes.