58566-85-1

Usage

Uses

Used in Pharmaceutical Industry:
1H-Benzimidazole-1-methanol,2-methyl-(9CI) is utilized as a pharmaceutical intermediate for the development of drugs targeting various therapeutic areas. Its unique structure allows for the creation of new drug candidates with potential applications in treating diseases and disorders.
Used in Organic Synthesis:
In the field of organic synthesis, 1H-Benzimidazole-1-methanol,2-methyl-(9CI) serves as a key building block for the synthesis of more complex organic molecules. Its reactivity and structural features make it a valuable component in the creation of novel compounds with diverse applications in various industries.

Upstream product

• 615-15-6 2-Methyl-1H-benzimidazole 
• 50-00-0 formaldehyd 

Relevant academic research and scientific papers

BENZIMIDAZOLYL COMPOUNDS AS POTENTIATORS OF MGLUR2 SUBTYPE OF GLUTAMATE RECEPTOR

Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

BENZIMIDAZOLYL COMPOUNDS

Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of formula (I) or pharmaceutically acceptable salts thereof, wherein Y1, R17, R2, R4, R5, R6, R7, R8, X2 and n are as defined in the detailed description of the invention. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

Application of ultrasound irradiation for the reactions of N-hydroxymethylation

A convenient and high yield method for the N-hydroxymethylation of substituted phthalimide and benzimidazole under ultrasound irradiation is reported.

A SELECTIVE SYNTHESIS OF UNSYMMETRICAL 1,1'-METHYLENEBISDIAZOLES BY SOLID-LIQUID PHASE TRANSFER CATALYSIS

1,1'-Methylenebisdiazoles Az1-CH2-Az2, Az1 and Az2 being two different diazoles, can be prepared selectively in three steps, through 1-hydroxymethyl- and 1-chloromethyldiazoles, by solid-liquid (S-L) phase transfer catalysis.