58577-61-0Relevant academic research and scientific papers
Bromoform activation. TiCl4-Mg-promoted CHBr2 - and CBr3- transfer to a variety of aldehydes and ketones
Yan, Tu-Hsin,Chang, Su-Haur,Chang, Cheng-Ta,Lin, Chia-Kuan,Liu, Chien-Yu
supporting information, p. 5802 - 5805 (2013/12/04)
TiCl4-Mg can mediate addition of CHBr3 to a variety of aldehydes and ketones to form dibromomethyl carbinols and also be used to effect CBr3 transfer to carbonyl groups to form tribromomethyl carbinols. The successful application of TiCl4-Mg-promoted coupling of CHBr3 with various carbonyl compounds, especially in the case of highly enolizable ketones such as 2-indanone and β-tetralone, highlights the extraordinary reactivity and selectivity and the weakly basic nature of this system.
Two effective procedures for the synthesis of trichloromethyl ketones, useful precursors of chiral α-amino and α-hydroxy acids
Corey,Link,Shao
, p. 3435 - 3438 (2007/10/02)
Trichloroacetic acid can be converted to trichloromethyl ketones in good yield by two practical new procedures, one involving the catalyzed reaction of trichloroacetic acid with aldehydes at 23°C followed by oxidation and the other utilizing the coupling
