5858-27-5

Basic information

• Product Name: 3-METHYL-2-NITROBENZALDEHYDE
• Synonyms: 3-METHYL-2-NITROBENZALDEHYDE;2-Nitro-m-tolualdehyde, 3-Formyl-2-nitrotoluene;3-Methyl-2-nitrobenzaldehyde 97%;3-Methyl-2-nitrobenzaldehyde97%
• CAS NO: 5858-27-5
• Molecular Formula: C₈H₇NO₃
• Molecular Weight: 165.14608
• Mol File: 5858-27-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 291.294°C at 760 mmHg
• Flash Point: 141.425°C
• Appearance: /
• Density: 1.278g/cm³
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.603
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 3-METHYL-2-NITROBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYL-2-NITROBENZALDEHYDE(5858-27-5)
• EPA Substance Registry System: 3-METHYL-2-NITROBENZALDEHYDE(5858-27-5)

Safety Data

• Hazardous Substances Data: 5858-27-5(Hazardous Substances Data)

Usage

General Description

3-Methyl-2-nitrobenzaldehyde is a chemical compound with the molecular formula C8H7NO3. It is a yellow crystalline solid that is commonly used as an intermediate in the production of various organic compounds, such as pharmaceuticals, dyes, and perfumes. It is also used as a reagent in organic synthesis and as a building block in the preparation of various materials. Additionally, 3-methyl-2-nitrobenzaldehyde has been studied for its potential biological activities, including its antimicrobial and antioxidant properties. However, it is important to handle this compound with care, as it is considered to be toxic if ingested and can cause irritation to the skin and eyes.

InChI:InChI=1/C8H7NO3/c1-6-3-2-4-7(5-10)8(6)9(11)12/h2-5H,1H3

Upstream product

• 50424-93-6 3-methyl-2-nitrobenzoyl chloride 
• 5437-38-7 3-methyl-2-nitrobenzoic acid 
• 522638-27-3 2-nitro-3-tetrahydropyran-2-yloxymethyltoluene 
• 80866-76-8 2-methyl-6-hydroxymethyl-1-nitrobenzene 

Downstream Products

• 5437-38-7 3-methyl-2-nitrobenzoic acid 
• 873692-26-3 diethyl 2-(3-methyl-2-nitrobenzylidene)malonate 
• 1256964-04-1 1-bis(4-methoxyphenyl)methyl-3-methyl-2-nitrobenzene 
• 1256964-01-8 1-bis[4-(N,N-dimethylamino)phenyl]methyl-3-methyl-2-nitrobenzene 
• 1256964-03-0 3-methyl-2-nitro-1-diphenylmethylbenzene 

Relevant articles and documents

Pendant Alkoxy Groups on N-Aryl Substitutions Drive the Efficiency of Imidazolylidene Catalysts for Homoenolate Annulation from Enal and Aldehyde

Hydrogen-transfer in the tetrahedral intermediate generated from an imidazolylidene catalyst and α,β-unsaturated aldehyde forms a conjugated Breslow intermediate. This is a critical step affecting the efficiency of the NHC-catalyzed γ-butyrolactone formation via homoenolate addition to aryl aldehydes. A novel type of imidazolylidene catalyst with pendant alkoxy groups on the ortho-N-aryl groups is described. Catalyst of this sort facilitates the formation of the conjugated Breslow intermediate. Studies of the rate constants for homoenolate annulation affording γ-butyrolactones, reveal that introduction of the oxygen atoms in the appropriate position of the N-aryl substituents can increase the efficiency of imidazolylidene catalysts. Structural and mechanistic studies revealed that pendant alkoxy groups can be located close to the proton of the tetrahedral intermediate, thereby facilitating the proton transfer.

Pyrrolo(oxo)quinolines as 5HT ligands

The present application provides pyrrolo(oxo)isoquinolines as modulators of serotonin receptors, pharmaceutical compositions containing such modulators and methods for treating various diseases, conditions and disorders associated with modulation of serot

Preparation and reaction of isomeric formyl-2,1-benzisoxazoles

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