58584-95-5

Basic information

• Product Name: 2,3,6-TRICHLORO-5-METHYLPYRIDINE
• Synonyms: 2,3,6-TRICHLORO-5-METHYLPYRIDINE
• CAS NO: 58584-95-5
• Molecular Formula: C₆H₄Cl₃N
• Molecular Weight: 196.46
• Mol File: 58584-95-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: 90-92 °C
• Boiling Point: 260.1±35.0 °C(Predicted)
• Appearance: /
• Density: 1.457±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -3.39±0.10(Predicted)
• CAS DataBase Reference: 2,3,6-TRICHLORO-5-METHYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,6-TRICHLORO-5-METHYLPYRIDINE(58584-95-5)
• EPA Substance Registry System: 2,3,6-TRICHLORO-5-METHYLPYRIDINE(58584-95-5)

Safety Data

• Hazardous Substances Data: 58584-95-5(Hazardous Substances Data)

Usage

General Description

2,3,6-Trichloro-5-methylpyridine is a highly toxic chemical compound that is primarily used as a pesticide and herbicide. It is classified as a chlorinated pyridine and is known for its strong herbicidal properties. This chemical is toxic to aquatic life and poses a risk to the environment. Its use is strictly regulated and monitored in order to prevent harm to humans and the environment. Exposure to 2,3,6-Trichloro-5-methylpyridine can cause skin and eye irritation, respiratory issues, and other health problems. Due to its toxicity, proper handling and disposal methods are crucial to prevent harm to living organisms and the environment.

Upstream product

• 29553-51-3 3-methyl-piperidine-2,6-dione 
• 18069-17-5 2-methylglutaric acid 
• 4553-62-2 2-methylglutaronitrile 
• 10026-13-8 phosphorus pentachloride 

Downstream Products

• 58584-88-6 2,5,6-trichloro-pyridine-3-carboxylic acid chloride 
• 54718-39-7 2,5,6-Trichloronicotinic Acid 

Relevant articles and documents

In vitro and in vivo evaluation of 6-aminopyrazolyl-pyridine-3- carbonitriles as JAK2 kinase inhibitors

Synthesis and biological evaluation of a series of 6-aminopyrazolyl- pyridine-3-carbonitriles as JAK2 kinase inhibitors was reported. Biochemical screening, followed by profile optimization, resulted in JAK2 inhibitors exhibiting good kinase selectivity, pharmacokinetic properties, physical properties and pharmacodynamic effects.

Synthesis and biological evaluation of aroylguanidines related to amiloride as inhibitors of the human platelet Na+/H+ exchanger

Pyridine and benzene bioisosteres of amiloride were synthesized and evaluated for their inhibitory potency against the sodium-hydrogen exchanger (NHE) involved in intracellular pH regulation. The inhibition of NHE was determined by using the platelet swelling assay (PSA) in which the swelling of human platelets was induced by their incubation in an acid buffer (pH 6.7). Additionally, the inhibitory potency of the most active compounds was assessed by measuring the inhibition of the EIPA-sensitive 22Na+ uptake (UIA) by human platelets after intracellular acidosis. The results indicated that several benzene derivatives and compounds bearing an carbonylguanidine moiety in the meta position of the pyridine nitrogen were much more potent than amiloride (PSA:IC50=43.5 μM; UIA:IC50=100.1 μM), but less than EIPA, a pyrazine NHE inhibitor (PSA:IC50=0.08 μM; UIA:IC50=0.5 μM). In both biological assays (2-amino-5-bromo-pyridine-3-carbonyl)guanidine (32) was the most active molecule (PSA:IC50=0.8 μM, UIA:IC50=0.8 μM). Our investigations demonstrated that the replacement of the pyrazine ring of amiloride by a pyridine or a phenyl ring improved the NHE inhibitory potency (phenyl >pyridine >pyrazine).