58588-64-0

Usage

Uses

Used in Pharmaceutical Industry:
3-Chloro-4-formylbenzonitrile is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs and enhance the properties of existing ones.
Used in Agrochemical Industry:
3-Chloro-4-formylbenzonitrile is used as an intermediate in the synthesis of agrochemicals to improve the effectiveness of pesticides and other agricultural products.
Used in Dye and Pigment Manufacturing:
3-Chloro-4-formylbenzonitrile is used as a key component in the manufacturing of dyes and pigments, contributing to the coloration and stability of these products.
Used in Organic Synthesis:
3-Chloro-4-formylbenzonitrile is used as a versatile building block in organic synthesis for its potential to create a wide range of fine chemicals and specialty compounds.
Safety Note:
It is important to handle 3-Chloro-4-formylbenzonitrile with caution, as it may be harmful if ingested, inhaled, or comes into contact with the skin. Proper safety measures should be taken during its use and storage to minimize potential health risks.

Upstream product

• 58588-63-9 4-Diacetoxymethyl-3-chlor-benzonitril 
• 21924-83-4 4-(bromomethyl)-3-chlorobenzonitrile 
• 79-46-9 2-nitropropane 
• 21423-81-4 3-chloro-4-methylbenzonitrile 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 1050477-54-7 3-chloro-4-[2-(dimethylamino)vinyl]benzonitrile 
• 105-07-7 4-cyanobenzaldehyde 

Downstream Products

• 58588-59-3 3-chloro-4-formylbenzoic acid 
• 914106-38-0 2-chloro-4-cyanobenzaldoxime 
• 959984-45-3 4-(2-acetyl-3-oxobut-1-en-1-yl)-3-chlorobenzonitrile 
• 105191-16-0 6-Cyanbenzothiophen-2-carbonsaeure-ethylester 
• 58588-61-7 3-Chloro-4-((E)-2-nitro-but-1-enyl)-benzoic acid 
• 58588-60-6 3-Chloro-4-((E)-2-nitro-propenyl)-benzoic acid 
• 914106-18-6 3-(2-chloro-4-cyanophenyl)-5-(3-cyanophenyl)isoxazole 
• 914106-10-8 3-(2-chloro-4-cyanophenyl)-5-(4-cyanophenyl)isoxazole 
• 914106-02-8 2-chloro-4-cyanobenzaldehyde chlorooxime 

Relevant academic research and scientific papers

Diverse ortho-C(sp2)-H functionalization of benzaldehydes using transient directing groups

Pd-catalyzed C-H functionalizations promoted by transient directing groups remain largely limited to C-H arylation only. Herein, we report a diverse set of ortho-C(sp2)-H functionalizations of benzaldehyde substrates using the transient directing group strategy. Without installing any auxiliary directing group, Pd(II)-catalyzed C-H arylation, chlorination, bromination, and Ir(III)-catalyzed amidation, could be achieved on benzaldehyde substrates. The transient directing groups formed in situ via imine linkage can override other coordinating functional groups capable of directing C-H activation or catalyst poisoning, significantly expanding the scope for metal-catalyzed C-H functionalization of benzaldehydes. The utility of this approach is demonstrated through multiple applications, including late-stage diversification of a drug analogue.

SUBSTITUTED 4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINAMIDES AND USE THEREOF

1,6-Naphthyridine or 8-azaquinazoline derivatives (I) are new. 1,6-Naphthyridine or 8-azaquinazoline derivatives of formula (I) are new. D : N or CR 4>; R 4> : H, F, CF 3 or 1-4C alkyl; Ar : 5-R 5>-6-R 6>-2-methyl-4-oxo-4H-1-benzopyran-8-yl; 3-R 6>-4-R 8>-1-naphthyl optionally substituted with 1-3 of R 7>; 7-R 6>-8-R 8>-5-quinolinyl optionally substituted with 1-2 of R 7>; or 2-R 9>-3-R 10>-4-R 8>-5-R 6>-phenyl; R 5> : H, F, Cl, CN, NO 2, CF 3 or 1-4C alkyl; R 6> : H or F; R 7> : halo, 1-4C alkyl, CF 3, 1-4C alkoxy or OCF 3; R 8> : CN or NO 2; R 9> : H or halo; optionally fluorinated 1-4C alkyl, 1-4C alkoxy, 1-4C alkylthio of di(1-4C alkyl)amino; or phenyl optionally substituted with halo, 1-4C alkyl or CF 3; R 10> : H, halo or 1-4C alkyl; R 1> : optionally fluorinated 1-4C alkyl; R 2> : 1-6C alkyl optionally substituted with 3-7C cycloalkyl or F; or SO 2R 11>; R 11> : 1-6C alkyl, CF 3 or 3-7C cycloalkyl; or phenyl or heteroaryl optionally substituted with 1-2 of halo, CN, 1-4C alkyl, CF 3, 1-4C alkoxy and/or OCF 3; R 3> : H, F, CF 3 or 1-4C alkyl. An independent claim is also included for a process for preparing (I). [Image] ACTIVITY : Hypotensive; Cardiant; Hepatotropic; Nephrotropic; Cerebroprotective. MECHANISM OF ACTION : Mineralocorticoid receptor (MR) antagonist. 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2-methyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide had an IC 50 of 35 nM when tested on cells expressing a GAL4-MR chimera.

SUBSTITUTED 4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINES AND USE THEREOF

The present application relates to novel substituted 4-aryl-1,4-dihydro-1,6-naphthyridines, a process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.

SUBSTITUTED-4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINAMIDES AND USE THEREOF

The present application relates to novel substituted 4-aryl-1,4-dihydro-1,6-naphthyridine-3-carboxamides, a process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.

Synthesis and in vitro antiprotozoal activities of dicationic 3,5-diphenylisoxazoles

3,5-Bis(4-amidinophenyl)isoxazole (3) - an analogue of 2,5-bis(4- amidinophenyl)furan (furamidine) in which the central furan ring is replaced by isoxazole - and 42 novel analogues were prepared by two general synthetic pathways. The 43 isoxazole derivati

Synthesis and antiprotozoal activity of dicationic 3,5-diphenylisoxazoles

Novel dicationic 3,5-diphenylisoxazole compounds are described. Synthetic routes to these novel compounds are provided. Several of the compounds displayed in vitro activity versus Trypanosoma brucei brucei and Plasmodium falciparum comparable to that of furamidine. A majority of the novel compounds also were less toxic to VERO cells than furamidine.

(Vinylaryloxy)acetic acids. A new class of diuretic agents. III. [(2 Nitro 1 alkenyl)aryloxy]acetic acids

A series of [(2 nitro 1 alkenyl)aryloxy]acetic acids was synthesized and tested in dogs for saluretic and diuretic activity. A number of these compounds exhibit a high order of activity on iv or po administration; representative of these is (E) [2,3 dichl