5860-70-8Relevant articles and documents
Efficient Synthesis of Nicotinic Acid Based Pseudopeptides Bearing an Amidoxime Function
Ovdiichuk, Olga V.,Hordiyenko, Olga V.,Medviediev, Volodymyr V.,Shishkin, Oleg V.,Arrault, Axelle
, p. 2285 - 2293 (2015)
The synthesis of nicotinic acid based amino acid units bearing an amidoxime function on the pyridine ring has been developed. The starting 2-cyanonicotinic acid was efficiently coupled with methyl esters of l-α-amino acids to afford intermediate 2-cyanopyridin-3-yl-containing pseudopeptides together with the tautomeric methyl esters of (2S)-2-(7-imino-5-oxo-5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl)alkanoic acids. Regioselective pyrrolidine ring opening of these esters occurred upon hydroxylamine hydrochloride treatment, giving rise to the open-chain pyridin-3-yl 2-amidoxime pseudopeptides bearing the same structure as amidoximes obtained by direct hydroxyamination of the corresponding cyano esters.
Method for synthesizing 2-aminopyridin-3-carboxylic acid
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Paragraph 0008; 0029, (2019/01/08)
The invention discloses a method for synthesizing 2-aminopyridin-3-carboxylic acid. The method utilizes 2, 3-pyridinedicarboxylic acid, acetic anhydride, ammonia water, hydrochloric acid, sodium hydroxide, bromine, 2-amidopyridin-3-carboxylic acid, CNTs and SnCl2.2H2O as main raw materials. Through ammonium acetate solution washing and sulfuric acid sulfonation, SnO2 of the coating layer is converted into solid super acid S-SnO2 so that the stability of the system is improved and the catalytic activity of the catalyst is improved. The method utilizes cheap and easily available raw materials, is safe in operation, realizes simple separation and purification and a high product yield and is suitable for large-scale preparation.
Preparation of substituted and unsubstituted 2-carbamoyl nicotinic and 3-quinolinecarboxylic acids
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, (2008/06/13)
The invention provides a process for the preparation of substituted and unsubstituted 2-carbamoyl nicotinic and 3-quinolinecarboxylic acids.