58605-12-2

Usage

Uses

Used in Chemical Synthesis:
METHYL 2,4-DINITROPHENYLACETATE is used as a chemical intermediate for the synthesis of various compounds. Its versatile structure allows for the creation of a wide range of products in the chemical industry.
Used in Biochemistry Research:
METHYL 2,4-DINITROPHENYLACETATE is used as a research tool in biochemistry, particularly for enzyme studies. Its nitrophenyl structure makes it a valuable compound for investigating enzyme mechanisms and interactions.

InChI:InChI=1/C9H8N2O6/c1-17-9(12)4-6-2-3-7(10(13)14)5-8(6)11(15)16/h2-3,5H,4H2,1H3

Upstream product

• 103-82-2 phenylacetic acid 
• 99-65-0 meta-dinitrobenzene 
• 96-32-2 bromoacetic acid methyl ester 
• 5199-50-8 methyl 2-iodoacetate 
• 67-56-1 methanol 
• 643-43-6 (2,4-dinitro-phenyl)-acetic acid 

Downstream Products

• 28691-50-1 6-Nitro-benzo[d]isoxazole-3-carboxylic acid 
• 643081-99-6 (2,4-diamino-phenyl)-acetic acid methyl ester 
• 474799-41-2 6-nitroindolin-2-one 
• 101084-96-2 2-methoxy-4-nitrobenzonitrile 
• 7251-09-4 4-amino-2-methoxybenzonitrile 
• 125112-64-3 5-nitro-2-pyridyl-(2-nitroso-4-nitrophenyl)carbomethoxycarbinol 
• 125112-61-0 2-quinolyl-(2-nitroso-4-nitrophenyl)carbomethoxymethyl carbinol 
• 186641-18-9 6-nitro-N-(1-benzyl-4-piperidinyl)-1,2-benzisoxazole-3-carboxamide 

Relevant academic research and scientific papers

Supramolecular kinetic effects by pillararenes: The synergism between spatiotemporal and preorganization concepts in decarboxylation reactions

A study about spontaneous decarboxylation reactions of 3-carboxy-1,2-benzisoxazole (CBI) nitrated derivatives (6-NitroCBI and 5,6-DinitroCBI) compared with supramolecular kinetic effects promoted by two cationic pillararenes (P5A and P6A) has been carried

SUBSTITUTED ARYL-AMINE DERIVATIVES AND METHODS OF USE

The present invention provides classes of compounds, including-their pharmaceutically acceptable derivatives, useful for treating angiogenesis and related diseases such as cancer. Formula I and II wherein R is a 9- or 10-membered heterocyclyl ring selected from 7-isoquinolinyl,..2-methyl-3-oxo-2,3-dihydroindazol-6-yl, [1,6]-naphthydrin-3-yl, [1,7]-naphthydrin-2-yl, 1-oxo-2,3-dihydrobenzofuran-4-yl, 3-oxo-2,3-dihydrobenzofuran-5-yl, dihydro-benzodioxinyl, 6-quinazolinyl, 2-amino-6-quinazolinyl, 4-methylamino-6-quinazolinyl, 2,4-diamino-6 quinazolinyl, 3-oxo-3,4-dihydro-1,4-benzoxazin-6-yl, 2,2-difluoro-l;3-benzodioxol-5-yl and 2,2,3,3 tetrafluoro-2,3-dihydro-l,4-benzodioxin-6-yl, each of which is optionally substituted with one or more substituents selected from halo, haloakyl, C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, N-dimethylamino-C1-6-alkyl, N-dimethylamino-C1-6-alkoxy, amino, alkyl-carbonylamino, morpholino-sulfonyl, amino-sulfonyl, oxazolyl, pyrrolyl,4 morpholinyl, carboxyl, cyano, and acetyl; wherein R1 in formula I is selected from unsubstituted or substituted phenyl, 5-6 membered heteroaryl, 9-10 membered bicyclic heterocyclyl and 11-14 membered tricyclic heterocyclyl, and R1 in formula II is selected from specific bicyclic heterocycles.

Substituted alkylamine derivatives and methods of use

Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

Synthesis and binding affinities of a series of 1,2-benzisoxazole-3-carboxamides to dopamine and serotonin receptors

A series of 1,2-benzisoxazole-3-carboxamides derived from tertiary cycloalkylamines was synthesized and evaluated for affinity for serotonergic (5-HT3 and 5-HT4) and dopaminergic (D2) receptors using radioligand binding as

Synthesis of 2-(2,6-dinitrophenyl)malonates, -acetates and acetonitrile by copper-mediated vicarious nucleophilic substitution

A regioselective, vicarious nucleophilic substitution of 1,3- dinitrobenzene with α-bromo- and iodocarbanions proceeds in the presence of copper(1) tert-butoxide and pyridine giving 2,6-dinitrophenylmalonates, 2,6- dinitrophenylacetates or 2,6-dinitrophenylacetonitrile as the only isomers from bromomalonate esters, bromoacetate esters, iodoacetate esters or iodoacetonitrile, respectively. Without copper(I) tert-butoxide, the 4- substituted isomer is the only product. We believe that the reaction proceeds via a σ-adduct of 1,3-dinitrobenzene and halocarbanion from which hydrogen and halogen are eliminated. This elimination is dependent upon the concentration of copper(I) tert-butoxide.