58621-39-9

Usage

Functional groups

a. Phenyl group
b. Ketone functional group
c. Hydroxy group attached to the phenyl ring

Applications

a. Production of pharmaceuticals
b. Organic synthesis

Potential properties

a. Antioxidant
b. Anti-inflammatory

Additional uses

a. Photosensitizer in dye-sensitized solar cells

Industrial applications

Various chemical and industrial applications due to its structure and properties

Upstream product

• 53327-14-3 2'-allyloxyacetophenone 
• 118-93-4 o-hydroxyacetophenone 
• 582-24-1 1-phenyl-2-hydroxyethanone 
• 106-95-6 allyl bromide 
• 49645-89-8 o-Hydroxyacetophenone sodium salt 

Downstream Products

• 67127-96-2 1-<2-hydroxy-3-(prop-1-enyl)phenyl>ethanone 
• 93915-84-5 1-(2-Hydroxy-3-propyl-phenyl)-ethanone 
• 198351-00-7 8-Allyl-2-p-tolyl-chromen-4-one 
• 198351-01-8 8-allyl-2-(4-chlorophenyl)-4H-chromen-4-one 
• 198351-03-0 8-Allyl-2-(2,4-dimethoxy-phenyl)-chromen-4-one 
• 198350-97-9 8-allyl-2-(2-methoxyphenyl)-4H-chromen-4-one 
• 198350-98-0 8-Allyl-2-(3-methoxy-phenyl)-chromen-4-one 
• 198350-99-1 8-allyl-2-(4-methoxyphenyl)-4H-chromen-4-one 
• 198351-05-2 8-Allyl-2-(3,4-dimethoxy-phenyl)-chromen-4-one 
• 198351-12-1 8-Allyl-2-(3,4,5-trimethoxy-phenyl)-chromen-4-one 
• 198351-10-9 8-Allyl-2-(2,3,4-trimethoxy-phenyl)-chromen-4-one 
• 198351-14-3 8-Allyl-2-(2,3,4,5-tetramethoxy-phenyl)-chromen-4-one 
• 198351-02-9 8-Allyl-2-(2,3-dimethoxy-phenyl)-chromen-4-one 
• 198351-04-1 8-Allyl-2-(2,5-dimethoxy-phenyl)-chromen-4-one 

Relevant academic research and scientific papers

Subsupercritical Water Generated by Inductive Heating Inside Flow Reactors Facilitates the Claisen Rearrangement

Claisen rearrangement of electron-deficient O-allylated phenols, including fluorine-modified phenols, is facilitated in aqueous media at high temperatures and pressures under flow conditions, as opposed to organic solvents. The O-allylation of phenols can be coupled with the Claisen rearrangement in an integrated flow system.

SUBSTITUTED 4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINAMIDES AND USE THEREOF

1,6-Naphthyridine or 8-azaquinazoline derivatives (I) are new. 1,6-Naphthyridine or 8-azaquinazoline derivatives of formula (I) are new. D : N or CR 4>; R 4> : H, F, CF 3 or 1-4C alkyl; Ar : 5-R 5>-6-R 6>-2-methyl-4-oxo-4H-1-benzopyran-8-yl; 3-R 6>-4-R 8>-1-naphthyl optionally substituted with 1-3 of R 7>; 7-R 6>-8-R 8>-5-quinolinyl optionally substituted with 1-2 of R 7>; or 2-R 9>-3-R 10>-4-R 8>-5-R 6>-phenyl; R 5> : H, F, Cl, CN, NO 2, CF 3 or 1-4C alkyl; R 6> : H or F; R 7> : halo, 1-4C alkyl, CF 3, 1-4C alkoxy or OCF 3; R 8> : CN or NO 2; R 9> : H or halo; optionally fluorinated 1-4C alkyl, 1-4C alkoxy, 1-4C alkylthio of di(1-4C alkyl)amino; or phenyl optionally substituted with halo, 1-4C alkyl or CF 3; R 10> : H, halo or 1-4C alkyl; R 1> : optionally fluorinated 1-4C alkyl; R 2> : 1-6C alkyl optionally substituted with 3-7C cycloalkyl or F; or SO 2R 11>; R 11> : 1-6C alkyl, CF 3 or 3-7C cycloalkyl; or phenyl or heteroaryl optionally substituted with 1-2 of halo, CN, 1-4C alkyl, CF 3, 1-4C alkoxy and/or OCF 3; R 3> : H, F, CF 3 or 1-4C alkyl. An independent claim is also included for a process for preparing (I). [Image] ACTIVITY : Hypotensive; Cardiant; Hepatotropic; Nephrotropic; Cerebroprotective. MECHANISM OF ACTION : Mineralocorticoid receptor (MR) antagonist. 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2-methyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide had an IC 50 of 35 nM when tested on cells expressing a GAL4-MR chimera.

Synthesis of novel 8-[2-hydroxy-3-(alkylamino)propyl]-4-methoxy coumarins

A series of new 8-[-2-hydroxy-3(alkylamino) propyl]-4-methoxy coumarins 7a-e, 8a-e have been synthesized from 3-allyl-2-hydroxy acetophenones 3a-e via key intermediate 8-(2-oxerane methyl)-4-methoxy coumarins 6a-e by regioselective opening of epoxide with

A general route for the stereoselective synthesis of (E)-(1-propenyl)phenyl esters by catalytic CC bond isomerization

A general and efficient procedure for the stereoselective synthesis of (E)-(1-propenyl)phenyl esters from readily accessible allylphenols has been developed. The process involves a two-step sequence consisting of the initial acylation of the allylphenols with an acid chloride, followed by catalytic CC bond isomerization in the resulting allylphenyl esters. The latter step was performed in methanol at 80 °C using catalytic amounts (0.5 mol %) of the commercially available bis(allyl)-ruthenium(IV) dimer [{RuCl(μ-Cl) (η3:η3-C10H16)} 2] (C10H16=2,7-dimethylocta-2,6-diene-1,8-diyl) . Reactions proceeded in high yields (68-93%) and short times (4-9 h) with complete E-selectivity.

Synthesis, in vitro antimicrobial and antioxidant activities of chalcone and flavone derivatives holding allylic substitutions

In a wide search program towards new and efficient biological active agents, a series of chalcone and flavone derivatives holding allylic substitutions have been synthesized and tested for their in vitro antibacterial and antifungal activities. The synthe

4-Chromenonyl-1,4-dihydropyridines and their use

The present application relates to novel 4-chromenonyl-1,4-dihydropyridines, process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis o

5-ARYL-SUBSTITUTED DIHYDROPYRIDOPYRIMIDINES AND DIHYDROPYRIDAZINES AND USE THEREOF AS MINERAL CORTICOID ANTAGONISTS

The present application relates to novel aryl-substituted heterobicyclic compounds, a process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prop

3-Cyano-5-thiazaheteroaryl-dihydropyridine and the use thereof for the treatment of cardiovascular diseases

The present application relates to novel aryl-substituted 3-cyano-5-thiazolyl- and 3-cyano-5-thiadiazolyl-1,4-dihydropyridines, a process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.

SUBSTITUTED 4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINES AND USE THEREOF

The present application relates to novel substituted 4-aryl-1,4-dihydro-1,6-naphthyridines, a process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.

SUBSTITUTED-4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINAMIDES AND USE THEREOF

The present application relates to novel substituted 4-aryl-1,4-dihydro-1,6-naphthyridine-3-carboxamides, a process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.