198350-99-1

Upstream product

• 58621-39-9 2-acetyl-6-allylphenol 
• 121-98-2 methyl 4-methoxybenzoate 
• 123-11-5 4-methoxy-benzaldehyde 
• 90-02-8 salicylaldehyde 
• 1307886-70-9 1-(2-(allyloxy)phenyl)-3-(4-methoxyphenyl)prop-2-yn-1-one 
• 768-60-5 4-methoxyphenylacetylen 
• 28752-82-1 2-(allyloxy)benzaldehyde 
• 118-93-4 o-hydroxyacetophenone 

Downstream Products

• 87627-10-9 [2-(4-Methoxy-phenyl)-4-oxo-4H-chromen-8-yl]-acetic acid 

Relevant academic research and scientific papers

Tandem Claisen Rearrangement/6-endo Cyclization Approach to Allylated and Prenylated Chromones

Allyl, dimethylallyl and prenyl ethers derived from o-acylphenols reacted upon microwave irradiation to form C-allylated or -prenylated chromone derivatives, depending on the substitution pattern of the arene and the allyl substituent. The reaction proceeds through a tandem Claisen rearrangement and 6-endo-trig or 6-endo-dig cyclization sequence. For prenyl ethers, the tandem sequence can be extended by a Cope rearrangement to furnish 6-prenylchromones. The method is potentially useful for the synthesis of natural products and drugs.

Synthesis and antitumour activity of new derivatives of flavone-8-acetic acid (FAA). Part 2: Ring-substituted derivatives

A range of 18 derivatives of flavone-8-acetic acid (FAA) with substituents on the 2-phenyl group have been prepared and their anti-tumour activity evaluated in vitro against a panel of human and murine tumour cell lines and in vitro against MAC 15A. There was no clear-cut relationship between in vitro and in vitro activity but the activity in each situation was found to be very sensitive to the precise substitution pattern with closely related isomers giving widely different activities. Some of the compounds, notably l0b,c,j, and r, were active in vitro and these require further studies in order to evaluate their potential for development.