58626-97-4

Usage

Uses

Used in Organic Synthesis:
[4-(Methylthio)phenyl]-hydrazinehydrochloride is used as a reagent in organic synthesis for its ability to form hydrazones, which serve as useful intermediates in the preparation of various organic compounds. [4-(Methylthio)phenyl]-hydrazinehydrochloride's reactivity, due to the presence of the methylthio group, allows for the creation of a broad spectrum of chemical products.
Used in Pharmaceutical Research:
In the pharmaceutical industry, [4-(Methylthio)phenyl]-hydrazinehydrochloride is utilized as a reagent for the development of new drugs. Its versatility and reactivity make it an essential component in the synthesis of potential pharmaceutical agents, contributing to the discovery and innovation of novel therapeutics.
Used in Laboratory Settings:
The hydrochloride salt form of [4-(Methylthio)phenyl]-hydrazinehydrochloride is used as a stable and easily handled reagent in laboratory settings. Its stability and ease of use make it a preferred choice for researchers working in organic chemistry, ensuring reliable results and facilitating the execution of complex chemical reactions.

InChI:InChI=1/C7H10N2S.ClH/c1-10-7-4-2-6(9-8)3-5-7;/h2-5,9H,8H2,1H3;1H

Upstream product

• 115171-09-0 N,N'-bis-(t-butoxycarbonyl)-4-(methylthio)phenylhydrazine 
• 104-96-1 4-methylsulfanylaniline 
• 104-95-0 (4-bromophenyl)thioanisole 
• 18620-04-7 4-thioanisolemagnesium bromide 

Downstream Products

• 572912-93-7 1-[4-(methylthio)phenyl]pyrazole 
• 903902-68-1 2,3,4,5-tetrahydro-8-methylthio-2-(phenylmethyl)-1H-pyrido[4,3-b]indole 
• 616209-43-9 1-(4-(methylthio)phenyl)-5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazole 
• 698350-38-8 1-(4-methylsulfonylphenyl)-5-(naphthalene-2-yl)-3-trifluoromethyl-1H-1,2,4-triazole 
• 1338216-18-4 C₁₈H₁₅F₃N₂OS 
• 1338216-19-5 C₁₉H₁₇F₃N₂OS 
• 1383843-39-7 1,3-bis(4-chlorobenzyl)-2-methyl-5-(methylthio)-1H-indole 
• 1383842-99-6 2-(1-(4-chlorobenzyl)-2-methyl-5-(methylthio)-1H-indol-3-yl)-N-(2-methoxypyridin-4-yl)-2-oxoacetamide 
• 1383843-27-3 2-(1-(4-chlorobenzyl)-2-methyl-5-(methylsulfonyl)-1H-indol-3-yl)-N-(2-methoxypyridin-4-yl)-2-oxoacetamide 
• 847233-92-5 3-(4-chlorophenoxy)-2-methyl-5-(methylsulfonyl)-1H-indole-1-acetic acid methyl ester 
• 847233-91-4 3-(4-chlorophenoxy)-2-methyl-5-(methylthio)-1H-indole-1-acetic acid methyl ester 

Relevant academic research and scientific papers

Synthesis of Aryl Hydrazines via CuI/BMPO Catalyzed Cross-Coupling of Aryl Halides with Hydrazine Hydrate in Water

The N,N’-bis(2,6-dimethylphenyl)oxalamide was discovered as a powerful ligand for Cu-catalyzed cross-coupling of aryl halides with hydrazine hydrate, leading to the formation of a variety of aryl hydrazines at 80 oC in water under the assistance of K3PO4 and 4 mol% cetyltrimethylammonium bromide from aryl bromides and aryl iodides. Good to excellent yields were observed in most cases.

CYP2C9 structure-metabolism relationships: Optimizing the metabolic stability of COX-2 inhibitors

The cytochrome P450 (CYP) family is composed of a large group of monooxygenases that mediate the metabolism of xenobiotics and endogenous compounds. CYP2C9, one of the major isoforms of the CYP family, is responsible for the phase I metabolism of a variety of drugs. The aim of the present investigation is to use rational design together with MetaSite, a metabolism site prediction program, to synthesize compounds that retain their pharmacological effects but that are metabolically more stable in the presence of CYP2C9. The model compound for the study is the nonsteroidal anti-inflammatory drug celecoxib, a COX-2 selective inhibitor and known CYP2C9 substrate. Thirteen analogs of celecoxib were designed, synthesized, and evaluated with regard to their metabolic properties and pharmacologic effects. The docking solutions and the predictions from MetaSite gave useful information leading to the design of new compounds with improved metabolic properties.

3-hetero-substituted-n-benzyl-indoles and prevention of leucotriene synthesis therewith

Compounds having the formula: STR1 are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion, dysmenorrhea, and migraine.

3-hetero-substituted-N-benzyl-indoles

Compounds having the formula: are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labour, spontaneous abortion, dysmenorrhea, and migraine.

ADDITION OF ARYLMETALLICS TO AZODICARBOXYLATES: A NOVEL SYNTHESIS OF ARYLHYDRAZINES BY AROMATIC HYDRAZINATION

Aryllithiums and arylmagnesium bromides add to the N=N bond of di-t-butyl azodicarboxylate, and subsequent acid deprotection provides the arylhydrazine.