58636-98-9Relevant academic research and scientific papers
Amination of heterocyclic compounds with O-benzoylhydroxylamine derivatives
Parlanti, Luca,Discordia, Robert P.,Hynes Jr., John,Miller, Michael M.,O'Grady, Harold R.,Shi, Zhongping
, p. 3821 - 3824 (2007)
The N-amination of heterocyclic compounds 1a - k with O- benzoylhydroxylamine derivatives 5 was developed and demonstrated to be a superior alternative to existing N-amination methods. A structure - reactivity relationship study was performed on variously
Development of a practical synthesis of a p38 kinase inhibitor via a safe and robust amination
Shi, Zhongping,Kiau, Susanne,Lobben, Paul,Hynes Jr., John,Wu, Hong,Parlanti, Luca,Discordia, Robert,Doubleday, Wendel W.,Leftheris, Katerina,Dyckman, Alaric J.,Wrobleski, Stephen T.,Dambalas, Konstantinos,Tummala, Srinivas,Leung, Simon,Lo, Ehrlic
, p. 1618 - 1625 (2013/02/23)
The development of a practical synthesis for a p38 kinase inhibitor is described. The key advances include an improved route to the key intermediate, a substituted pyrrole, and a subsequent animation utilizing O-(4-nitrobenzoyl)- hydroxylamine, which provides a safe, scalable, and robust amination method. The new protocol was successfully demonstrated to generate 1.6 kg of API in seven steps and 26% overall yield.
Method for preparing pyrrolotriazine compounds
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Page/Page column 6, (2008/06/13)
A method for aminating pyrrole derivatives and for preparing pyrrolotriazine compounds having the formula V,
