586375-09-9

Upstream product

• 53937-02-3 4-(benzyloxy)pyridin-2(1H)-one 
• 1194-02-1 4-fluorobenzonitrile 

Downstream Products

• 586375-13-5 methyl-4-[3-chloro-4-[(2,4-difluorobenzyl)oxy]-2-oxypyridin-1(2H)-yl]benzoate 
• 586375-16-8 methyl-4-[4-[(2,4-difluorobenzyl)oxy]-2-oxypyridin-1(2H)-yl]benzoate 
• 586375-15-7 4-[4-[(2,4-difluorobenzyloxy)]-2-oxopyridin-1(2H)-yl]benzonitrile 
• 586375-14-6 1-[4-nitrilephenyl]-4-hydroxy-2(1H)-pyridinone 
• 586374-55-2 4-[4-(benzyloxy)-3-bromo-2-oxopyridin-1(2H)-yl]benzonitrile 

Relevant academic research and scientific papers

SUBSTITUTED PYRIDINONES

Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.