586378-69-0

Basic information

• Product Name: 2(1H)-Pyridinone, 4-hydroxy-6-methyl-1-(2-pyridinylmethyl)- (9CI)
• Synonyms: 2(1H)-Pyridinone, 4-hydroxy-6-methyl-1-(2-pyridinylmethyl)- (9CI);4-Hydroxy-6-methyl-1-pyridin-2-ylmethyl-1H-pyridin-2-one
• CAS NO: 586378-69-0
• Molecular Formula: C12H12N2O2
• Molecular Weight: 216.23588
• Product Categories: ALCOHOL
• Mol File: 586378-69-0.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2(1H)-Pyridinone, 4-hydroxy-6-methyl-1-(2-pyridinylmethyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Pyridinone, 4-hydroxy-6-methyl-1-(2-pyridinylmethyl)- (9CI)(586378-69-0)
• EPA Substance Registry System: 2(1H)-Pyridinone, 4-hydroxy-6-methyl-1-(2-pyridinylmethyl)- (9CI)(586378-69-0)

Safety Data

• Hazardous Substances Data: 586378-69-0(Hazardous Substances Data)

Usage

Structure

A pyridinone ring with a hydroxyl group at position 4, a methyl group at position 6, and a pyridinylmethyl group attached to position 1.

Type

A derivative of pyridinone.

Usage

Often used as a building block in organic synthesis.

Potential applications

May have potential pharmaceutical applications due to its structural features.

Biological activity

The presence of the pyridinylmethyl group suggests that it may have biological activity.

Further research

Needed to fully understand the potential uses and effects of this compound.

Upstream product

• 3731-51-9 2-(Aminomethyl)pyridine 
• 675-10-5 4-hydroxy-6-methyl-2-pyron 

Downstream Products

• 636581-73-2 2-amino-5-(5-methyl-3-oxo-4-pyridin-2ylmethyl-cyclohexa-1,5-dienyl)-3-nitro-benzoic acid methyl ester 

Relevant articles and documents

Design, Synthesis, and Phenotypic Profiling of Pyrano-Furo-Pyridone Pseudo Natural Products

Natural products (NPs) inspire the design and synthesis of novel biologically relevant chemical matter, for instance through biology-oriented synthesis (BIOS). However, BIOS is limited by the partial coverage of NP-like chemical space by the guiding NPs. The design and synthesis of “pseudo NPs” overcomes these limitations by combining NP-inspired strategies with fragment-based compound design through de novo combination of NP-derived fragments to unprecedented compound classes not accessible through biosynthesis. We describe the development and biological evaluation of pyrano-furo-pyridone (PFP) pseudo NPs, which combine pyridone- and dihydropyran NP fragments in three isomeric arrangements. Cheminformatic analysis indicates that the PFPs reside in an area of NP-like chemical space not covered by existing NPs but rather by drugs and related compounds. Phenotypic profiling in a target-agnostic “cell painting” assay revealed that PFPs induce formation of reactive oxygen species and are structurally novel inhibitors of mitochondrial complex I.

Discovery of N-substituted pyridinones as potent and selective inhibitors of p38 kinase

The identification and evolution of a series of potent and selective p38 inhibitors is described. p38 inhibitors based on a N-benzyl pyridinone high-throughput screening hit were prepared and their SAR explored. Their design was guided by ligand bound co-