586381-87-5Relevant academic research and scientific papers
Discovery of PH-797804, a highly selective and potent inhibitor of p38 MAP kinase
Selness, Shaun R.,Devraj, Rajesh V.,Devadas, Balekudru,Walker, John K.,Boehm, Terri L.,Durley, Richard C.,Shieh, Huey,Xing, Li,Rucker, Paul V.,Jerome, Kevin D.,Benson, Alan G.,Marrufo, Laura D.,Madsen, Heather M.,Hitchcock, Jeff,Owen, Tom J.,Christie, Lance,Promo, Michele A.,Hickory, Brian S.,Alvira, Edgardo,Naing, Win,Blevis-Bal, Radhika,Messing, Dean,Yang, Jerry,Mao, Michael K.,Yalamanchili, Gopi,Vonder Embse, Richard,Hirsch, Jeffrey,Saabye, Matthew,Bonar, Sheri,Webb, Elizabeth,Anderson, Gary,Monahan, Joseph B.
scheme or table, p. 4066 - 4071 (2011/08/02)
The synthesis and SAR studies of a novel N-aryl pyridinone class of p38 kinase inhibitors are described. Systematic structural modifications to the HTS lead, 5, led to the identification of (-)-4a as a clinical candidate for the treatment of inflammatory diseases. Additionally, the chiral synthesis and properties of (-)-4a are described.
