586388-06-9

Upstream product

• 134970-24-4 3-acetoxy-17α-(E)-<2-(tri-n-butylstannyl)ethenyl>estra-1,3,5(10)-trien-17β-ol 
• 134970-25-5 3-acetoxy-17α-(Z)-<2-(tri-n-butylstannyl)ethenyl>estra-1,3,5(10)-trien-17β-ol 
• 1765-93-1 4-fluoroboronic acid 
• 91085-40-4 3-acetoxy-(17α,20Z)-21-(iodo)-19-norpregna-1,3,5(10),20-tetraene-17β-ol 
• 91085-40-4 17α,20E-21-iodo-19-norpregna-1,3,5(10),20-tetraene-3,17β-diol 3-acetate 

Relevant academic research and scientific papers

Synthesis and evaluation of (17α,20Z)-21-(4-substituted-phenyl)-19- norpregna-1,3,5(10),20-tetraene-3,17β-diols as ligands for the estrogen receptor-α hormone binding domain: Comparison with 20E-isomers

As part of our ongoing program to develop probes for the hormone binding domain of the estrogen receptor-α (ERα), we prepared and evaluated a series of 17α,Z-(4-substituted-phenyl)-vinyl estradiol derivatives. The results indicated that the relative bindi

Synthesis and evaluation of 17alpha-20E-21-(4-substituted phenyl)-19-norpregna-1,3,5(10),20-tetraene-3,17beta-diols as probes for the estrogen receptor alpha hormone binding domain.

As part of our program to develop probes for the hormone binding domain of the estrogen receptor alpha (ERalpha), we prepared a series of 4-para-substituted phenylvinyl estradiol derivatives using a combination of solution and solid-phase Pd(0)-catalyzed