58648-36-5

Upstream product

• 105543-51-9 dimethyl 3,4-dibromoadipate 
• 18424-76-5 dimethyl malonate sodium salt 
• 1119-43-3 (E,E)-hexa-2,4-dienedioic acid dimethyl ester 
• 108-59-8 malonic acid dimethyl ester 
• 1830-54-2 3-oxopentanedioic acid dimethyl ester 
• 131543-46-9 Glyoxal 
• 78698-09-6 Vossen's Red Salt 

Downstream Products

• 51716-63-3 cis-bicyclo[3. 3. 0]octane-3,7-dione 

Relevant academic research and scientific papers

DIHYDROPTERIDINONE DERIVATIVES, PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF

Dihydroperidinone derivatives, preparation process and pharmaceutical use thereof are disclosed. Specially, new dihydroperidinone derivatives represented by general formula (I), wherein each substituent of the general formula (I) is defined as in the description, their preparation process, pharmaceutical compositions comprising said derivatives and their use as therapeutical agents, especially as Plk kinase inhibitors are disclosed.

DIHYDROPTERIDINONE DERIVATIVES, PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF

Dihydroperidinone derivatives, preparation process and pharmaceutical use thereof are disclosed. Specially, new dihydroperidinone derivatives represented by general formula (I), wherein each substituent of the general formula (I) is defined as in the description, their preparation process, pharmaceutical compositions comprising said derivatives and their use as therapeutical agents, especially as Plk kinase inhibitors are disclosed.

General approach for the synthesis of polyquinanes. Facile generation of molecular complexity via reaction of 1,2-dicarbonyl compounds with dimethyl 3-ketoglutarate

The condensation of dimethyl 3-ketoglutarate 1 with 1,2-dicarbonyl compounds provides access to the polyquinane derivatives tricyclo[6.3.0.01,S]undecane-3,7,9-trione 27, tricyclo[3.3.3.01,s]undecane 31; tetra-cyclo[5.5.1.04,13.010,13]-tridecane-2,6,8,12-tetraone 41; tetracycloI6.6.0.0u.0,l3ltetradecane-2,7,9,14-tetraone 44; and the tetracyclo(5.5.1.01013]tridecane triones Sb and 6b. The unique structure of staurane tetraone 41 has resulted in spontaneous resolution of the two antipodes on crystallization from DMF. In addition, examination of the crystal structures of tetraones 41 and 44, in terms of strain energy, coupled with the steric accessibility of the /5-diketone functionality contained in 41 and 44 have been employed to explain why tetraone 44 and trione 27 undergo a retro-Claisen reaction (CH3OH) more rapidly than staurane tetraone 41.