58652-19-0

Usage

Uses

Used in Hormonal Contraception:
17-hydroxy-6-methylene-19-norpregn-4-ene-3,20-dione 17-acetate is used as a progestin medication for hormonal contraception. It is often combined with estrogen in oral contraceptives to provide effective birth control by preventing ovulation and making it difficult for sperm to reach the egg and for a fertilized egg to implant in the uterus.
Used in Gynecological Disorders Treatment:
In the medical industry, 17-hydroxy-6-methylene-19-norpregn-4-ene-3,20-dione 17-acetate is used as a therapeutic agent for the treatment of various gynecological disorders. Its action on progesterone receptors helps regulate hormonal balance and alleviate symptoms associated with such conditions.

InChI:InChI=1/C23H30O4/c1-13-11-20-18(17-6-5-16(26)12-19(13)17)7-9-22(4)21(20)8-10-23(22,14(2)24)27-15(3)25/h12,17-18,20-21H,1,5-11H2,2-4H3/t17-,18-,20-,21+,22+,23?/m1/s1

Upstream product

• 1624-58-4 17α-hydroxy-3-methoxy-19-norpregna-1,3,5(10)-trien-20-one 
• 14328-46-2 20,20-(ethylenedioxy)-3-methoxy-17α-hydroxy-19-norpregna-1,3,5(10)-triene 
• 2137-18-0 17-alpha-Hydroxy-19-norprogesterone 
• 53-16-7 Estrone 
• 31981-44-9 17α-acetoxy-19-norpregna-4-ene-3,20-dione 
• 147508-40-5 6-formyl-3-ethoxy-17α-acetoxy-19-norpregna-3,5-diene-20-one 
• 1624-62-0 estrone 3-methyl ether 
• 72-33-3 mestranol 

Downstream Products

• 58652-20-3 nomegestrol acetate 

Relevant academic research and scientific papers

An improved synthesis of nomegestrol acetate

Oral contraceptives (OCs) are synthetic steroids, or progestins, which are structurally related to testosterone or to progesterone. Many progestins have been synthesized and approved for OCs, hormonal replacement therapy (HRT), or the treatment of some gynecological disorders. Nomegestrol acetate (NOMAc) is a newly approved OC and has gained rapid acceptance in many countries for OC or HRT. The synthesis of NOMAc remains challenging and costly. We have developed a novel and improved procedure for the synthesis of NOMAc with a total of 11 steps and an overall good yield without the use of hazardous reagents.

3,20-Diketo, 6-methyl, 17-alpha-hydroxy 19-norpregna 4,6-diene, its esters and the uses thereof

A novel 3,20-diketo, 6-methyl, 17-alpha hydroxy 19-norpregna-4,6-diene is disclosed, along with a method for its production from 17-alpha-hydroxy 19-nor-progesterone acetate. The 17-alpha acetic ester, and the 17-alpha saturated or unsaturated aliphatic carboxylic acid esters (having up to 11 carbon atoms) of the compound, are also disclosed. The compound and its derivatives are useful in the treatment of luteal deficiency, hyperestrogenic or hyperandrogenic conditions, and seborrhea, either simple or complicated with acne.