58655-09-7Relevant academic research and scientific papers
On the Reaction of Dithiocarbamates with Nitrogen-Containing Derivatives of Oxalic Acid
Fueloep, Vilmos,Kalman, Alajos,Beckert, Rainer,Fabian, Juergen
, p. 561 - 570 (1989)
The action of bisimidochlorides of oxalic acid on dithiocarbamates produces 2-thioxo-3-aryl(alkyl)-4,5-diiminothiazolidines by cycloacylation.The molecular structure of 2-thioxo-3-(4-methoxyphenyl)-4,5-bis(phenylimino)-thiazolidine is confirmed by X-ray crystal structure analysis. - Keywords: Derivatives of oxalic acid; Dithiocarbamates; MNDO-Calculation; NS-Heterocycles; X-ray diffraction
Synthesis of 4-Substituted Thiosemicarbazones of 3-Methyl-4-phenylpyridine-2-carboxaldehyde as Antitumor Agents
Rahman, M. F.
, p. 828 - 830 (2007/10/02)
A convenient synthesis of 3-methyl-4-phenylpyridine-2-carboxaldehyde (4) is described.Reaction of 4 with 4-substituted thiosemicarbazides (6) gives thiosemicarbazones (7) some of which (7b, 7g, 7i and 7j) exhibit significant antitumor activity in animals.Thiosemicarbazides (6e - 6j) have been prepared from the corresponding isothiocyanates (5) (which result from sodium chlorite oxidation of the addition products of CS2 and the appropriate amine) and hydrazine.Isomerisation of 1,3-dimethyl-4-phenyl-1,2,3,6-tetrahydropyridine (Δ4-isomer) to 1,2,5,6-tetrahydro analog (Δ3-isomer, 1) has been effected with refluxing conc.HCl.
