58658-03-0Relevant academic research and scientific papers
Acridone Derivate Simultaneously Featuring Multiple Functions and Its Applications
Xia, Yaokun,He, Wenhui,Li, Juan,Zeng, Lupeng,Chen, Tingting,Liao, Yijuan,Sun, Weiming,Lan, Jianming,Zhuo, Shuangmu,Zhang, Jing,Yang, Huanghao,Chen, Jinghua
, p. 8406 - 8414 (2019/06/17)
Compared with plenty of single-functional molecules, multifunctional molecules are scarce and have high demand in further research. In this work, a multifunctional molecule called 10-methyl-2-amino-acridone (MAA) is presented. Interestingly, MAA simultaneously features electrochemistry, two-photon fluorescence, visible-light-induced oxidase mimic, and photoelectrochemistry (PEC) activity, and the related properties are studied in detailed. Multiple functions integrated into one molecule allow MAA to become a versatile signal probe. Therefore, the MAA acted as an electrochemical indicator to detect exosomal total protein with high sensitivity at first. In addition, MAA is used for one- or two-photon fluorescence imaging in vitro and in vivo, including cells, three-dimensional (3D) tumor spheroids, zebrafish, and exosomes. The results suggest that MAA not only possesses favorable photostability, but it is also suitable for imaging in deep tissue. Furthermore, the visible-light-induced oxidase mimic and photoelectrochemical activities of MAA are selectively inhibited by Cu2+, and the relevant mechanism is carefully analyzed. On the basis of this phenomenon, we develop a dual-modal detection strategy for detection of Cu2+ in river water. Compared with a single signal readout model, this strategy is able to avoid false positive and negative detection through two series of data mutually validating each other. Therefore, our study shows that the "multiple-in-one" MAA provides a blueprint for the investigation and application of a multifunctional organic molecule.
Fluorescent nitric oxide donor for the detection and killing of: Pseudomonas aeruginosa
Hibbard, Hailey A. J.,Reynolds, Melissa M.
, p. 2009 - 2018 (2019/03/26)
The epidemic of multidrug-resistant bacteria calls for the improvement of both detection methods for bacterial infections and methods of treatment. Nitric oxide is a known potent antibacterial agent, but due to its gaseous and highly reactive nature, it is difficult to incorporate into a stable antibacterial compound. In this paper, we synthesize a nitric oxide donor attached to a fluorescent compound, creating a material that can both detect and kill the deadly multi-drug resistant bacteria strain Pseudomonas aeruginosa. Detection occurs through a bacterial enzyme-activated color change, showing a clear and obvious change from blue to yellow under UV light. The synthesized compound spontaneously releases 853 μmol of nitric oxide/g from a 10 mM initial concentration. Antibacterial efficacy studies after exposing Pseudomonas aeruginosa to a 10 mM dose of the synthesized compound show a 55-75% reduction in bacteria after 24 hours. This work is the first instance of a small molecule dual-function material that can both detect and kill bacteria.
Two-photon fluorescent probe 10-methyl-2-amino-acridone as well as preparation method and application thereof
-
Paragraph 0014, (2017/11/30)
The invention discloses two-photon fluorescent probe 10-methyl-2-amino-acridone as well as a preparation method and application thereof. The 10-methyl-2-amino-acridone is used as a fluorescent probe and is used for living imaging of cells and zebra fishes. The structural formula of the 10-methyl-2-amino-acridone is shown in the description. The compound has good water solubility; emission wavelength of the compound is a green light wave band; with good two-photon activity, bioautofluorescence and self-absorption can be well reduced, and the compound is successfully applied to imaging of the cells and the zebra fishes; meanwhile, the compound has good electrochemical activity, and is expected to be applied to the field of electrochemical sensing as a novel electro-active indicator.
