58658-11-0Relevant academic research and scientific papers
Development of acridine derivatives as selective Mycobacterium tuberculosis DNA gyrase inhibitors
Medapi, Brahmam,Meda, Nikhila,Kulkarni, Pushkar,Yogeeswari, Perumal,Sriram, Dharmarajan
, p. 877 - 885 (2016/05/24)
In this study we have designed p-phenylene diamine linked acridine derivative from our earlier reported quinoline-aminopiperidine hybrid MTB DNA gyrase inhibitors with aiming more potency and less cardiotoxicity. We synthesized thirty six compounds using four step synthesis from 2-chloro benzoic acid. Among them compound 4-chloro-N-(4-((2-methylacridin-9-yl)amino)phenyl)benzenesulphonamide (6) was found to be more potent with MTB DNA gyrase super coiling IC50of 5.21 ± 0.51 μM; MTB MIC of 6.59 μM and no zHERG cardiotoxicity at 30 μM and 11.78% inhibition at 50 μM against mouse macrophage cell line RAW 264.7.
NOVEL HDMX INHIBITORS AND THEIR USE FOR CANCER TREATMENT
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Paragraph 0033; 0035; 0036, (2015/11/30)
The present invention provides for novel acridine-like class of compounds that have demonstrated efficiency in treating cancer. The compounds of the present invention have demonstrated efficacy in binding to and antagonizing the activity of the p53 repres
Identification of an Acridine Photoaffinity Probe for Trypanocidal Action
Firth, William J.,Messa, Andrew,Reid, Robert,Wang, Rung Chou (Charles),Watkins, Charles L,Yielding, Lerena W.
, p. 865 - 870 (2007/10/02)
Twenty-four acridine derivatives were screened for trypanocidal activity in Trypanosoma brucei in order to determine which structural features of the acridine molecule confer maximal antiparasitic activity.The syntheses of several new azidoacridine deriva
