58663-24-4Relevant academic research and scientific papers
SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE
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Page/Page column 31, (2008/06/13)
The present invention relates to pyrimidinones and pyridones and derivatives thereof, and pharmaceutically acceptable salts thereof. Also included is a method of treatment of inflammation, rheumatoid arthritis, Pagets disease, osteoporosis, multiple myeloma, uveititis, acute or chronic myelogenous leukemia, pancreatic ? cell destruction, osteoarthritis, rheumatoid spondylitis, gouty arthritis, inflammatory bowel disease, adult respiratory distress syndrome (ARDS), psoriasis, Crohn's disease, allergic rhinitis, ulcerative colitis, anaphylaxis, contact dermatitis, asthma, muscle degeneration, cachexia, Reiter's syndrome, type I diabetes, type II diabetes, bone resorption diseases, graft vs. host reaction, Alzheimer's disease, stroke, myocardial infarction, ischemia reperfusion injury, atherosclerosis, brain trauma, multiple sclerosis, cerebral malaria, sepsis, septic shock, toxic shock syndrome, fever, myalgias due to HIV-1, HIV-2, HIV-3, cytomegalovirus (CMV), influenza, adenovirus, the herpes viruses or herpes zoster infection in a mammal comprising administering an effective amount a compound as described above.
Phenylalkylamines and salts thereof
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, (2008/06/13)
Compounds of the formula STR1 wherein R1 is hydrogen, --(CH2)n --R4 or --CO--R5, where n is 1 or 2, R4 is hydrogen, cyano or benzoyl, and R5 is hydrogen, lower alkoxy, benzyloxy, --CH2 --NH2, --CH(CH3)--NH2, --CH2 --NH--CH2 --C6 H5 or --CH(CH3)--NH--CH2 --C6 H5, R2 is hydrogen or methyl, and R3 is amino, nitro, --NH--CO--R6 or --NH--A--R7, where R6 is hydrogen, methyl, methoxy, ethoxy, methylthio or ethylthio, R7 is amino, methylamino or dimethylamino, and A is --CO-- or --SO2 --, and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as hypertensives.
