58686-69-4Relevant academic research and scientific papers
Ruthenium-catalyzed [2+2] cycloaddition reactions of a 2-oxa-3- azabicyclo[2.2.1]hept-5-ene with unsymmetrical alkynes
Durham, Robin,Mandel, Jeremie,Blanchard, Nicolas,Tam, William
scheme or table, p. 1494 - 1505 (2012/01/12)
Ruthenium-catalyzed [2+2] cycloaddition reactions of a 2-oxa-3- azabicyclo[2.2.1]hept-5-ene with unsymmetrical alkynes were investigated. Yields of up to 90% were obtained though regioselectivity was modest. Select cycloadducts could be separated and used to access a highly functionalized [3.2.0] bicyclic structure through reductive cleavage of the N-O bond. These ring-opened products displayed a chemical exchange phenomenon in 1D carbon NMR and required characterization by 2D NMR techniques.
Ligand-free copper(Ι)-catalyzed Sonogashira-type coupling of arylboronic acids with terminal alkynes
Pan, Changduo,Luo, Fang,Wang, Wenhui,Ye, Zhishi,Cheng, Jiang
supporting information; scheme or table, p. 5044 - 5046 (2009/12/05)
An efficient ligand-free CuI-catalyzed Sonogashira-type coupling reaction of arylboronic acids with terminal alkynes under air is described. The electron-deficient alkynes gave the desired cross-coupling products in good yields. Thus, it represents a simple and alternative method for the traditional Sonogashira reaction.
