586960-22-7

Usage

Uses

Used in Agricultural Industry:
(2E)-3-(4-isopropoxyphenyl)acrylic acid is used as a herbicidal agent for the purpose of controlling the growth of broadleaf weeds and grasses in agricultural fields. It is applied to inhibit their cell wall synthesis, thereby preventing the formation of cellulose and hemicellulose, which are essential components of plant cell walls. This action leads to the stunting of growth and the eventual death of the targeted plants, thus aiding in the cultivation of desired crops without competition from weeds.
Furthermore, due to its low toxicity and quick environmental breakdown, (2E)-3-(4-isopropoxyphenyl)acrylic acid is favored as an eco-friendly alternative in weed management strategies, ensuring minimal impact on the environment and non-target species.

InChI:InChI=1/C12H14O3/c1-9(2)15-11-6-3-10(4-7-11)5-8-12(13)14/h3-9H,1-2H3,(H,13,14)/b8-5+

Upstream product

• 75-30-9 2-iodo-propane 
• 3943-97-3 methyl 4-hydroxycinnamate 
• 141-82-2 malonic acid 
• 18962-05-5 4-isopropoxybenzaldehyde 
• 123-08-0 4-hydroxy-benzaldehyde 

Downstream Products

• 79669-11-7 4-hydroxyphenylpropionic acid isopropyl ether 

Relevant academic research and scientific papers

COMPOUNDS, SALTS THEREOF AND METHODS FOR TREATMENT OF DISEASES

The present disclosure relates to compounds according to Formulae (I), (II) and (VIII), useful for treating diseases.

Development of sulfonamides incorporating phenylacrylamido functionalities as carbonic anhydrase isoforms I, II, IX and XII inhibitors

A series of novel sulfonamides incorporating phenylacrylamido functionalities were synthesized and investigated for the inhibition of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1). The physiologically and pharmacologically relevant human (h) isoforms hCA I and II (cytosolic isozymes), as well as the transmembrane tumor-associated hCA IX and XII were included in the study. These compounds showed low nanomolar or sub-nanomolar inhibition constants against hCA II (KIs in the range of 0.50–50.5 nM), hCA IX (KIs of 1.8–228.5 nM), and hCA XII (KIs of 3.5–96.2 nM) being less effective as inhibitors of the off target isoform hCA I. A detailed structure–activity relationship study demonstrates that the nature and position of substituents present on the aromatic part of the scaffold strongly influence the inhibition of CA isoforms. As hCA II, IX and XII are involved in pathologies such as glaucoma and hypoxic, and metastatic tumors, compounds of the type reported in this work may be useful preclinical candidates.

PHENYLALKYLCARBOXYLIC ACID DELIVERY AGENTS

The present invention provides phenylalkylcarboxylic acid compounds and compositions containing such compounds which facilitate the delivery of biologically active agents.

Competitive formation of β-amino acids, propenoic, and ylidenemalonic acids by the Rodionov reaction from malonic acid, aldehydes, and ammonium acetate in alcoholic medium

The Rodionov reaction of 49 available aliphatic and aromatic aldehydes with malonic acid and ammonium acetate in alcoholic medium, resulting in formation of β-amino acids, propenoic, and ylidenemalonic acids, was studied. Certain regioselectivity regularities of the reaction were revealed. Among the variety of ketones studied, cyclohexanone is the only whose reaction yields a β-amino acid. Unusual dehydrofluorination of 6-chloro-2-fluorocinnamic acid under the Rodionov reaction was discovered. 2005 Pleiades Publishing, Inc.