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4-(3-bromophenyl)-N-(2-chlorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide is a complex organic compound with a molecular formula of C16H13BrClN4OS. It is a derivative of pyrimidine, a heterocyclic aromatic organic compound consisting of a six-membered ring, with four carbon atoms and two nitrogen atoms. This specific compound features a 6-methyl group, a 2-thioxo group, and a 5-carboxamide functional group. The presence of 3-bromophenyl and 2-chlorophenyl groups attached to the pyrimidine ring further enhances its chemical properties. 4-(3-bromophenyl)-N-(2-chlorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide is primarily used in pharmaceutical research and development, particularly in the synthesis of potential therapeutic agents targeting various diseases. Its unique structure and functional groups make it an interesting candidate for further exploration in medicinal chemistry.

5871-66-9

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5871-66-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 5871-66-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,8,7 and 1 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 5871-66:
(6*5)+(5*8)+(4*7)+(3*1)+(2*6)+(1*6)=119
119 % 10 = 9
So 5871-66-9 is a valid CAS Registry Number.

5871-66-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-(3-bromophenyl)-N-(2-chlorophenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide

1.2 Other means of identification

Product number -
Other names 2-pyridin-3-yl-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:5871-66-9 SDS

5871-66-9Downstream Products

5871-66-9Relevant academic research and scientific papers

Design, synthesis and biological evaluation of benzothiazepinones (BTZs) as novel non-ATP competitive inhibitors of glycogen synthase kinase-3β (GSK-3β)

Zhang, Peng,Hu, Hai-Rong,Bian, Shi-Hui,Huang, Zhao-Hui,Chu, Yong,Ye, De-Yong

, p. 95 - 103 (2013/04/23)

Glycogen synthase kinase-3β (GSK-3β) plays a key role in type II diabetes and Alzheimer's diseases, to which non-ATP competitive inhibitors represent an effectively therapeutical approach due to their good specificity. Herein, a series of small molecules benzothiazepinones (BTZs) as novel non-ATP competitive inhibitors of GSK-3β have been designed and synthesized. The in vitro evaluation performed by luminescent assay showed most BTZ derivatives have inhibitory effects in micromolar scale. Among them compounds 6l, 6t and 6v have the IC50 values of 25.0 μM, 27.8 μM and 23.0 μM, respectively. Moreover 6v is devoid of any inhibitory activity in the assays to other thirteen protein kinases. Besides, SAR is analyzed and a hypothetical enzymatic binding mode is proposed by molecular docking study, which would be useful for new candidates design.

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