58737-22-7

Usage

Uses

Used in Pharmaceutical Industry:
P-AMINOPHENYL-1-THIO-BETA-D-GLUCOPYRANOS IDE is used as a key intermediate compound for the preparation of CCR5 antagonists, which are anti-HIV-1 agents. Its unique structure allows it to be a crucial component in the development of these life-saving medications, contributing to the fight against HIV-1.
Used in Chemical Synthesis:
P-AMINOPHENYL-1-THIO-BETA-D-GLUCOPYRANOS IDE is also used as a starting material to synthesize functionalized Coumarins (C755380), which are known as acetylcholinesterase inhibitors. These inhibitors play a vital role in the treatment of various neurological disorders, such as Alzheimer's disease, by regulating the levels of acetylcholine in the brain.

Upstream product

• 1193-02-8 4-aminotiophenol 
• 2492-87-7 4-nitrophenyl-β-D-glucoside 
• 22566-82-1 1-thio-β-D-glucopyranose 
• 540-37-4 p-aminoiodobenzene 

Relevant academic research and scientific papers

Enzymatic Synthesis of a Series of Thioglycosides: Analogs of Arbutin with Efficient Antipigmentation Properties

Arbutin, a natural glycoside, is well known as a commercial tyrosinase inhibitor, and thus, to prevent pigmentary disorders of skin. In fact, tyrosinase is involved in the biosynthesis of melanin, the skin main pigment. However, arbutin is subject to hydr

Nickel-catalyzed arylation, alkenylation, and alkynylation of unprotected thioglycosides at room temperature

Unprotected thioglycosides were effective nucleophiles for Ni 0-catalyzed C-S bond-forming reaction with functionalized (hetero)aryl, alkenyl, and alkynyl halides. The functional-group tolerance on the electrophilic partner was typically high a

Substituted phenyl-1-thio(poly-O-sulfo)-α(or β)-D-glucopyranosides

Cation salts of substituted phenyl-1-thio(poly-O-sulfo)-α(or β)-D-glucopyranoside, useful as modulators of the complement system, the intermediates thereof and the process of making such intermediates and end products.