5875-50-3Relevant articles and documents
INVESTIGATIONS IN THE FIELD OF ACYL GROUP CARRIERS. XVI. HYDROLYTIC STABILITY AND ENZYMATIC DEPHOSPHORYLATION OF D-PANTOTHENIC ACID 4'-PHOSPHATE
Kopelevich, V. M.,Lysenkova, A. V.,Mishchenko, V. V.,Gunar, V. I.,Pron'ko, P. S.,Moiseenok, A. G.
, p. 360 - 364 (1981)
Samples of D-pantothenic acid 4'-phosphate (I) have been investigated by IR spectroscopy in dimethyl sulfoxide and deuterated water and in the form of a thin film without a solvent.The vibrations of the carbonyl and amide groupings in (I) as compared with pantothenic acid (II) are found at higher frequencies in all media, which indicate the greater strength of these bonds.It is assumed that the resistance of (I) to hydrolysis as compared with (II) is due to the inclusion of the phosphate in a macrocycle by the formation of hydrogen bonds between the phosphate, hydroxy, amide, and carboxy groups of the molecule.The complete dephosphorylation of (I) has been achieved in concentrations of 0.0075 and 0.005 mM with the aid of a dialyzed preparation of orthophosphate monoester phosphohydrolase (E.C. 3.1.3.1).
Identification of Specific and Nonspecific Inhibitors of Bacillus anthracis Type III Pantothenate Kinase (PanK)
Shapiro, Justin A.,Varga, John J.,Parsonage, Derek,Walton, William,Redinbo, Matthew R.,Ross, Larry J.,White, E. Lucile,Bostwick, Robert,Wuest, William M.,Claiborne, Al,Goldberg, Joanna B.
, p. 78 - 82 (2018/12/13)
Antibiotics with novel mechanisms of action are desperately needed to combat the increasing rates of multidrug-resistant infections. Bacterial pantothenate kinase (PanK) has emerged as a target of interest to cut off the biosynthesis of coenzyme A. Herein we report the results of an in vitro high-throughput screen of over 10 000 small molecules against Bacillus anthracis PanK, as well as a follow-up screen of hits against PanK isolated from Pseudomonas aeruginosa and Burkholderia cenocepacia. Nine hits are structurally categorized and analyzed to set the stage for future drug development.
