5876-17-5

Usage

Uses

Used in Pharmaceutical Industry:
4,8-Dimethoxyfuro[2,3-b]quinolin-7-ol is used as a pharmaceutical compound for its potential therapeutic properties. Its alkaloid nature and unique structure make it a candidate for further research and development in the field of medicine.
Used in Chemical Research:
4,8-Dimethoxyfuro[2,3-b]quinolin-7-ol is also used as a subject of study in chemical research, particularly in the investigation of alkaloid structures, their properties, and potential applications in various fields.

References

Sidyakin, Yunusov, Dokl. Akad. Nauk. Uzbek SSR, 4, 39 (1962) Fakhritdinova, Sidyakin, Yunusov,Khim.Prir. Soedin., 1, 107 (1965)

InChI:InChI=1/C13H11NO4/c1-16-11-7-3-4-9(15)12(17-2)10(7)14-13-8(11)5-6-18-13/h3-6,14H,1-2H3

Upstream product

• 110548-95-3 evoxine 
• 58480-57-2 4-(4,8-dimethoxy-furo[2,3-b]quinolin-7-yloxy)-2-methyl-but-2-en-1-ol 
• 52336-91-1 7-benzyloxy-4,8-dimethoxy-furo[2,3-b]quinoline 
• 56775-80-5 7-(2'-hydroxy-3'-methoxy-prenyloxy)-4,8-dimethoxyfuroquinoline 
• 58480-58-3 acetylhaplatine 
• 55740-46-0 4,8-dimethoxy-furo[2,3-b]quinolin-7-yl tri-O-acetyl-α-L-6-deoxy-mannopyranoside 
• 83-95-4 skimmianine 
• 865878-27-9 4-chloro-7,8-dimethoxy-furo[2,3-b]quinoline 
• 865878-14-4 (7S,8R)-4-methoxy-7,8-dihydrofuro[2,3-b]quinoline-7,8-diol 
• 186581-53-3 diazomethane 
• 119188-51-1 4-methoxyfuro[2,3-b]quinoline-7,8-diol 
• 115345-33-0 haplosinine 
• 115345-32-9 haplosidine 
• 107783-37-9 haplobine 

Downstream Products

• 83-95-4 skimmianine 
• 482-32-6 kokusagine 
• 23417-92-7 7-isopentenyloxy-γ-fagarine 
• 5876-30-2 O-(3,4,5-trimethoxybenzoyl)haplopine 

Relevant academic research and scientific papers

Biphenyl dioxygenase-catalysed cis-dihydroxylation of tricyclic azaarenes: Chemoenzymatic synthesis of arene oxide metabolites and furoquinoline alkaloids

Biotransformation of acridine, dictamnine and 4-chlorofuro[2,3-b]quinolone, using whole cells of Sphingomonas yanoikuyae B8/36, yielded five enantiopure cyclic cis-dihydrodiols, from biphenyl dioxygenase-catalysed dihydroxylation of the carbocyclic rings.

cis-dihydrodiol, arene oxide and phenol metabolites of dictamnine: Key intermediates in the biodegradation and biosynthesis of furoquinoline alkaloids

Biotransformation of the parent furoquinoline alkaloid dictamnine and its 4-chlorofuroquinoline precursor, using the B8/ 36 bacterial mutant strain of Sphingomonas yanoikuyae, yielded, via biphenyl dioxygenase-catalysed dihydroxylation, the first isolable alkaloid cis-dihydrodiol metabolites; these metabolites were used in the chemoenzymatic synthesis of postulated arene oxide and phenol intermediates, and a range of derived furoquinoline alkaloids. The Royal Society of Chemistry 2005.

STRUCTURE OF HAPLOSIDINE

A new glycoalkaloid, haplosidine, has been isolated from the epigeal part of the plant Haplophyllum perforatum, and its structure has been established as 7- 3)-2'-O-acetyl-α-L-rhamnopyranosyloxy>-4,8-dimethoxyfuranoquinoline.

HAPLOSININE - A NEW FURANOQUINOLINE GLYCOALKALOID FROM Haplophyllum perforatum

The new glycoalkaloid haplosinine has been isolated from the epigeal part of Haplophyllum perforatum (M.B.) Kar. et Kir., and its structure has been established on the basis of chemical transformations and a comparative analysis of its 13C NMR spectra with those of known compounds as haplopine 7-O-3)-α-L-rhamnopyranoside>.

ALKALOIDS OF THE ROOTS OF THE Haplophyllum obtusifolium

The roots of the Haplophyllum obtusifolium Lebed. have been yielded robustine, dictamnine, skimmianine, γ-fagarine, and evoxine and the new alkaloid haplobine for which on the basis of spectral characteristics and a passage to the main alkaloid haplopine (7-hydroxy-4,8-dimethoxylfuranoquinoline) the structure of 7-(3'-chloromethylbut-2'-enyloxy)-4,8-dimethoxyfuranoquinoline has been established.