58775-83-0

Usage

Uses

Used in Chemical Research and Industrial Applications:
1-Ethynyl-3-phenoxy-benzene is utilized as a building block for the synthesis of more complex organic molecules, serving as a key component in the development of advanced materials and compounds.
Used in Pharmaceutical and Agrochemical Production:
1-ETHYNYL-3-PHENOXY-BENZENE is employed as a precursor in the production of other pharmaceuticals and agrochemicals, contributing to the creation of new drugs and agricultural products that can address various health and agricultural needs.
Used in Organic Synthesis:
Due to its potential as a reactive intermediate, 1-Ethynyl-3-phenoxy-benzene is used in various chemical processes within the field of organic synthesis, enabling the formation of a wide range of chemical products with diverse applications.
Used in Materials Science:
The unique properties of 1-Ethynyl-3-phenoxy-benzene make it an important compound in materials science, where it can be incorporated into the design and synthesis of new materials with specific properties for various applications.

InChI:InChI=1/C14H10O/c1-2-12-7-6-10-14(11-12)15-13-8-4-3-5-9-13/h1,3-11H

Upstream product

• 1044571-55-2 C₁₇H₁₆O₂ 
• 39515-51-0 3-Phenoxybenzaldehyde 
• 108-36-1 1,3-dibromobenzene 
• 558-13-4 carbon tetrabromide 

Downstream Products

• 1020533-78-1 3-(1,1-difluoroethyl)diphenylether 
• 63444-54-2 3-ethenylphenyl phenyl ether 
• 1370017-43-8 1-fluoro-2-(3-phenoxyphenyl)acetylene 
• 1428143-48-9 5-(3-phenoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole 

Relevant academic research and scientific papers

BTK Inhibitors and uses thereof

The invention discloses a bruton's tyrosine kinase (BTK) inhibitor and use thereof. Specifically, the invention provides heteroaromatic compounds or stereoisomers, geometrical isomers, tautomers, racemates, nitrogen oxides, hydrates, solvates, metabolites and pharmaceutically acceptable salts or prodrugs thereof, and pharmaceutical compositions containing the heteroaromatic compounds; the invention also discloses use of the heteroaromatic compounds or the pharmaceutical compositions containing the heteroaromatic compounds in preparation of medicines; the medicines can be used for treating autoimmune diseases, inflammatory diseases or proliferative diseases.

DBU-Mediated Synthesis of Aryl Acetylenes or 1-Bromoethynylarenes from Aldehydes

Two well known synthetic organic reactions Ramirez olefination and Corey-fuchs reactions are integrated in one-pot sequential manner for the synthesis of arylacetylenes and 1,3-enynes starting directly from commercially available aldehydes. The bicyclic amidine 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) along with additive NaOH not only exclusively afforded the terminal alkynes directly from the aldehydes, but also enhanced the reaction rate. The dynamic nature of DBU also facilitated the isolation of 1-bromoalkynes intermediate products. Selection of additive from NaOH and H2O served as a switch for the synthesis of terminal alkyne and 1-bromoalkynes, respectively. (Figure presented.).

The Dual Role of 1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU) in the Synthesis of Terminal Aryl- and Styryl-Acetylenes via Umpolung Reactivity

The dual role of the bicyclic amidine base 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) was demonstrated in a synthesis of terminal aryl- and styryl-acetylenes. Mechanistically, a tandem process involving elimination/Umpolung/protonation occurs in a single step to generate terminal aryl- and styryl-acetylenes from geminal dibromoalkenes. The key to the success of this transformation lies in the organobase-mediated generation of the acetylide from the 1-bromoalkynes at room temperature. The unique characteristics of DBU as an inherently safer reagent make it an attractive alternative to previous systems wherein required pyrophoric reagents and nonambient temperatures remain unsolved issues. The procedure does not work for the synthesis of alkyl-acetylenes.

Electrochemical carboxylation of α,α-difluorotoluene derivatives and its application to the synthesis of α-fluorinated nonsteroidal anti-inflammatory drugs

Electrochemical carboxylation of α,α-difluorotoluene derivatives resulted in an efficient fixation of carbon dioxide to give the corresponding α-fluorophenylacetic acids in good yields, and this reaction was successfully applied to the synthesis of α-fluorinated nonsteroidal anti-inflammatory drugs (NSAIDs). Georg Thieme Verlag Stuttgart.