58777-87-0

Usage

Uses

Used in Pharmaceutical Industry:
1-(4-METHOXY-PHENYL)-2-METHYLAMINO-ETHANOL could be used as an active pharmaceutical ingredient for [specific medical condition or treatment] due to its phenol ether and secondary amine properties, which may offer therapeutic benefits.
Used in Chemical Synthesis:
In the chemical synthesis industry, 1-(4-METHOXY-PHENYL)-2-METHYLAMINO-ETHANOL may serve as a key intermediate or reactant in the production of other organic compounds, leveraging its unique structural features.
Used in Material Science:
1-(4-METHOXY-PHENYL)-2-METHYLAMINO-ETHANOL could be utilized as a component in the development of new materials with specific properties, such as improved solubility, reactivity, or stability, depending on the requirements of the application.
Used in Research and Development:
In academic and industrial research settings, 1-(4-METHOXY-PHENYL)-2-METHYLAMINO-ETHANOL may be employed as a subject of study to explore its chemical properties, potential reactions, and applications in various fields.
[Please provide specific application types and reasons if available, as the above are general hypotheses based on the compound's structure and category.]

InChI:InChI=1/C10H15NO2/c1-11-7-10(12)8-3-5-9(13-2)6-4-8/h3-6,10-12H,7H2,1-2H3

Upstream product

• 186581-53-3 diazomethane 
• 532-80-9 synephrine 
• 87920-02-3 p-Methoxy-N-methyl-mandelsaeureamid 
• 637-69-4 4-Methoxystyrene 
• 532-80-9 (+)-Synephrine 
• 87920-02-3 4-methoxy-L-mandelic acid-methylamide 
• 104383-29-1 methyl (S)-α-hydroxy-(4-methoxyphenyl)acetate 
• 123-11-5 4-methoxy-benzaldehyde 
• 1431664-68-4 C₁₁H₁₅NO₂ 
• 91013-24-0 3-amino-4-methoxy-DL-mandelic acid-methyl ester 
• 13305-14-1 methyl 2-hydroxy-2-(4-methoxyphenyl)acetate 
• 74-88-4 methyl iodide 
• 227015-96-5 O-tert-butyl-N-<2-hydroxy-2-(4-methoxyphenyl)ethyl>-N-methyl carbamate 

Downstream Products

• 387355-55-7 1-(4-methoxyphenyl)-2-(1-methylhydrazino)ethanol hydrogen fumarate 
• 568583-64-2 N-(4-chlorobenzyl)-2-{[[2-hydroxy-2-(4-methoxyphenyl)ethyl](methyl)amino]methyl}-4-methyl-7-oxo-4,7-dihydrothieno[3,2-b]pyridine-6-carboxamide 

Relevant academic research and scientific papers

Design and Scalable Synthesis of N-Alkylhydroxylamine Reagents for the Direct Iron-Catalyzed Installation of Medicinally Relevant Amines**

Secondary and tertiary alkylamines are privileged substance classes that are often found in pharmaceuticals and other biologically active small molecules. Herein, we report their direct synthesis from alkenes through an aminative difunctionalization reaction enabled by iron catalysis. A family of ten novel hydroxylamine-derived aminating reagents were designed for the installation of several medicinally relevant amine groups, such as methylamine, morpholine and piperazine, through the aminochlorination of alkenes. The method has excellent functional group tolerance and a broad scope of alkenes was converted to the corresponding products, including several drug-like molecules. Besides aminochlorination, the installation of other functionalities through aminoazidation, aminohydroxylation and even intramolecular carboamination reactions, was demonstrated, further highlighting the broad potential of these new reagents for the discovery of novel amination reactions.

A simple two-step synthesis of 2-(alkylamino)-1-arylethanols, including racemic adrenaline, from aromatic aldehydes via 5-aryloxazolidines

Benzaldehydes react smoothly with nonstabilized azomethine ylides, generated in situ from sarcosine/formaldehyde or N-(methoxymethyl)-N- (trimethylsilylmethyl)benzylamine, to give 5-aryloxazolidines as intermediates. These were converted into 2-(alkylamino)-1-arylethanols in good yields by simple heating in methanol with hydrochloric acid, or by treatment with hydrazine hydrate in ethanol.

α-Aminated methyllithium by DTBB-catalysed lithiation of a N- (chloromethyl) carbamate

The reaction of O-tert-butyl-N-(chloromethyl)-N-methyl carbamate (1) with lithium powder and a catalytic amount of 4,4'-di-tert-butylbiphenyl (DTBB, 2.5 mol %) in the presence of different electrophiles [Me3SiCl, (i)BuCHO, (t)BuCHO, PhCHO, 4-MeOC6H4CHO, (CH2)4CO, MeCO(n)Pr, Et2CO, MeCO(CH2)2CH=CH2, PhCOMe, PhCO(n)Bu, Ph2CO] in THF at -78°C leads, after hydrolysis with water, to the expected functionalised carbamates 2. Carbamates 2 derived from carbonyl compounds are deprotected with hydrogen chloride (for aromatic aldehyde or ketone derivatives) or with a mixture of phenol and trimethylsilyl chloride (for aliphatic aldehyde derivatives) giving substituted 1,2-diols 4.

Di- and tri-substituted oxazolidin-2-one oximes

Certain di- and tri- substituted oxazolidin-2-one oximes have antidepressant activity in warm blooded animals. Exemplary is 4-methyl-5-phenyl-2-oxazolidinone oxime.