5878-33-1

Usage

Uses

Used in Organic Chemistry Research:
Bis(8-methyl-8-azabicyclo[3.2.1]oct-3-yl) 1,2,3,4-tetrahydro-1-phenylnaphthalene-1,4-dicarboxylate is used as a key intermediate in the synthesis of various organic compounds and derivatives. Its unique structure allows for the development of new chemical entities with potential applications in different fields.
Used in Pharmaceutical Development:
Due to its potential pharmaceutical properties, bis(8-methyl-8-azabicyclo[3.2.1]oct-3-yl) 1,2,3,4-tetrahydro-1-phenylnaphthalene-1,4-dicarboxylate is employed as a precursor in the production of certain drugs and organic compounds. Its ability to form various derivatives makes it a promising candidate for the development of new therapeutic agents.
Used in Chemical Industry:
Bis(8-methyl-8-azabicyclo[3.2.1]oct-3-yl) 1,2,3,4-tetrahydro-1-phenylnaphthalene-1,4-dicarboxylate is utilized as a versatile building block in the chemical industry for the production of a wide range of organic compounds. Its unique structure and reactivity contribute to the synthesis of novel materials with diverse applications.

InChI:InChI=1/C34H42N2O4/c1-35-23-12-13-24(35)19-22(18-23)34(33(38)40-27-8-4-3-5-9-27)17-16-30(29-10-6-7-11-31(29)34)32(37)39-28-20-25-14-15-26(21-28)36(25)2/h3-11,22-26,28,30H,12-21H2,1-2H3

Upstream product

• 2292-08-2 tropine hydrochloride 
• 14054-31-0 2-phenyl-acrylic acid tropan-3-yl ester 
• 51-55-8 Atropine 
• 101-31-5 Hyoscyamine 
• 7647-01-0 hydrogenchloride 
• 7664-93-9 sulfuric acid 
• 55-48-1 (1R,3r,5S)-3-tropoyloxytropanium sulfate 
• 55-48-1 atropine sulphate 
• 101716-26-1 (+/-)-1-phenyl-1,2,3,4-tetrahydro-naphthalene-1r,4t-dicarbonyl chloride 

Downstream Products

• 2292-11-7 3exo-bromo-tropane 
• 492-38-6 2-phenylacrylic acid 
• 7432-10-2 Tropanol 

Relevant academic research and scientific papers

On the analytics and the stability of atropine sulphate and scopolamine hydrobromide. III. Studies on the stability of tropane alkaloids; Part 80: Contributions to problems concerning the use of plastic containers for liquid pharmaceuticals

On evaluating their investigations, the authors discuss the degradation mechanism of tropane alkaloids in aqueous solution. As evidenced by competitive and consecutive reactions (hydrolysis, dehydration, dimerization), the degradation mechanism is characterized by a complicated course. Apart from temperature, a series of other factors, above all the pH value, exerts a considerable effect on the stability of both the alkaloids. Unbuffered solutions are more stable than buffered ones. The isothermal short-time test is not suitable for stability prediction. In the long-time test it was found that unbuffered aqueous atropine sulphate solutions still contained 90% of their initial drug content after 18 months' storage in low-density polyethylene containers at 20° C. Scopolamine hydrobromide solutions showed an almost analogous behavior. Of the container materials tested, low-density polyethylene bottles have been found to be best suited.

Analysis and stability of atropine sulfate and scopolamine hydrobromide. 1. Qualitative detection of alkaloids in the presence of their decomposition products. 73. Contribution to the problem of the use of plastic receptacles for liquid pharmaceuticals

The authors deal with the qualitative determination of tropane alkaloid salts (atropine sulphate and scopolamine hydrobromide) in aqueous solutions in the presence of their decomposition products using thin-layer chromatography. Aqueous solutions of these tropane alkaloid salts were tested for stability after storage in glass and polyethylene containers under various conditions (pH value, temperature, ultra-violet irradiation, oxidative effects). Besides tropine, apoatropine, alpha- and beta-belladonine, further decomposition products showing a basic reaction (and in part not yet identified) were detected. The stability of solid atropine sulphate was studied by means of differential thermal analysis and mass spectrometry.