587886-96-2Relevant academic research and scientific papers
Ag(I) complexes of benzimidazol-2-ylidene ligands: A study of catalytic efficiency towards three-component coupling reactions
Kilin?arslan, Rafet,Sadi?, Naim,?etinkaya, Bekir
, p. 681 - 687 (2016)
The N -heterocyclic carbene (NHC)-Ag(I) complexes 3a-c were synthesized from benzimidazolium chlorides (2a-c = NHC.HCl), incorporating benzyl derivatives and a 2-methoxyethyl group (a: 3N = 2,4,6-trimethylbenzyl; b: 3N = 2,3,5,6-tetr
Efficient in situ N-heterocyclic carbene palladium(ii) generated from Pd(OAc)2 catalysts for carbonylative Suzuki coupling reactions of arylboronic acids with 2-bromopyridine under inert conditions leading to unsymmetrical arylpyridine ketones: synthesis, characterization and cytotoxic activities
Touj, Nedra,Al-Ayed, Abdullah S.,Sauthier, Mathieu,Mansour, Lamjed,Harrath, Abdel Halim,Al-Tamimi, Jamil,?zdemir, Ismail,Ya?ar, Sedat,Hamdi, Naceur
, p. 40000 - 40015 (2019/01/03)
N,N-Substituted benzimidazole salts were successfully synthesized and characterized by 1H-NMR, 13C {1H} NMR and IR techniques, which support the proposed structures. Catalysts generated in situ were efficiently used for the carbonylative cross-coupling reaction of 2 bromopyridine with various boronic acids. The reaction was carried out in THF at 110 °C in the presence of K2CO3 under inert conditions and yields unsymmetrical arylpyridine ketones. All N,N-substituted benzimidazole salts 2a-i and 4a-i studied in this work were screened for their cytotoxic activities against human cancer cell lines such us MDA-MB-231, MCF-7 and T47D. The N,N-substituted benzimidazoles 2e and 2f exhibited the most cytotoxic effect with promising cytotoxic activity with IC50 values of 4.45 μg mL?1 against MDA-MB-231 and 4.85 μg mL?1 against MCF7 respectively.
Palladium PEPPSI complexes: Synthesis and catalytic activity on the Suzuki-Miyaura coupling reactions for aryl bromides at room temperature in aqueous media
Touj, Nedra,Gürbüz, Nevin,Hamdi, Naceur,Ya?ar, Sedat,?zdemir, ?smail
, p. 187 - 194 (2018/04/20)
A new series of palladium N-heterocyclic carbene complexes having methoxyethyl on the side chain (3a–d, 4a–e) have been synthesized and fully characterized by NMR, HRMS and IR. Next, the palladium-NHC-PEPPSI complexes 3a-e and 4a-e were used as catalyst in Suzuki-Miyaura coupling reactions were investigated for aryl bromides at room temperature in aqueous media. 3a-d and 4a-e complexes showed good catalytic activity for electron-donating or electron-drawing aryl bromides with arylboronic acid. Complex 4b exhibited higher activity compared to other analogues due to bearing more electronically donating NHC ligands.
Sonogashira cross-coupling reaction catalysed by mixed NHC-Pd-PPh3 complexes under copper free conditions
Touj, Nedra,Ya?ar, Sedat,?zdemir, Nam?k,Hamdi, Naceur,?zdemir, ?smail
, p. 59 - 71 (2018/02/27)
Mixed NHC–Pd–PPh3 complexes with a methoxyethyl-substituted N-heterocyclic carbene (NHC) were synthesised and characterised by NMR, HRMS, elemental analysis and X-ray crystallography for complex 3b. These complexes were applied to Sonogashira c
Direct arylation of arene C-H bonds by cooperative action of NHCarbene-Ruthenium(II) catalyst and carbonate via proton abstraction mechanism
Oezdemir, Ismail,Demir, Serpil,Cetinkaya, Bekir,Gourlaouen, Christophe,Maseras, Feliu,Bruneau, Christian,Dixneuf, Pierre H.
, p. 1156 - 1157 (2008/09/20)
Direct functionalization of sp2 C-H bonds via ortho diarylation of 2-pyridyl benzene with arylbromides was achieved using ruthenium(II) catalysts containing a RuCl2(NHC) unit and generated from [RuCl2(arene)]2 and two types of NHC precursors, pyrimidinium and benzimidazolium salts, in the presence of Cs2CO3. DFT calculations from RuCl2(NHC)(2-pyridylbenzene) show that a proton abstraction mechanism, on cooperative actions of both the coordinated base and the Ru(II) center, is favored via a 13.7 kcal·mol-1 exothermic process affording an orthometalated intermediate with a 2.009 A Ru-C bond. Copyright
